Naslov
High-Throughput Glycome Analysis Is Set To Join High-Throughput Genomics

Autori
Rudd, Pauline M. ; Rudan, Igor ; Wright, Alan F.

Izvornik
Journal of Proteome Research (1535-3893) 8 (2009), 3; 1105-1106

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
genomics; glycomics; high-throughput methods; genome-wide association studies

Sažetak
Glycomics involves the comprehensive study of the entire complement of sugars attached to glycoconjugates within an organism or its components. Detailed structural analysis of the glycome complements information derived from genomics and proteomics analyses. This analysis provides a holistic view of molecules and organisms and brings glycobiology into mainstream systems biology. It would be a mistake to continue to view glycosylation as an independent parameter because, clearly, glycosylation processing pathways are integrated into complex, multifactorial systems. Glycosylation is cell-, protein-, and site-specific, and hundreds of genes and proteins are involved in the processing of complex glycans. This argues in favor of strong genetic regulation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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