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Pregled bibliografske jedinice broj: 434978

Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives

Radić Stojković, Marijana; Marjanović, Marko; Pawlica, Dariusz; Dudek, Lukasz; Eilmes, Julita; Kralj, Marijeta; Piantanida, Ivo
Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives // New journal of chemistry, 34 (2010), 3; 500-507 doi:10.1039/b9nj00490d (međunarodna recenzija, članak, znanstveni)

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Naslov
Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives

Autori
Radić Stojković, Marijana ; Marjanović, Marko ; Pawlica, Dariusz ; Dudek, Lukasz ; Eilmes, Julita ; Kralj, Marijeta ; Piantanida, Ivo

Izvornik
New journal of chemistry (1144-0546) 34 (2010), 3; 500-507

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
dibenzotetraaza[14]annulene ; DNA and RNA polynucleotides ; spectrophotometric titrations ; antiproliferative activity ; tumour cell lines

Sažetak
Studied dicationic dibenzotetraaza[14]annulene derivatives intercalate into synthetic double stranded DNA and RNA, while their positively charged side-chains additionally interact within the minor groove of polynucleotides, contributing to the overall affinity of compounds and controlling pronounced A-T(U) over G-C sequence preference as well as stronger thermal stabilization of ds-DNA than ds-RNA. Furthermore, all compounds showed moderate to high antiproliferative activity against five human tumour cell lines, whereby clear correlation between structure of the side-chain and cytotoxic activity was observed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Kralj, Marijeta, MZOS ) ( CroRIS)
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Ivo Piantanida (autor)

Avatar Url Marko Marjanović (autor)

Avatar Url Marijana Radić Stojković (autor)

Avatar Url Marijeta Kralj (autor)

Poveznice na cjeloviti tekst rada:

doi www.rsc.org

Citiraj ovu publikaciju:

Radić Stojković, Marijana; Marjanović, Marko; Pawlica, Dariusz; Dudek, Lukasz; Eilmes, Julita; Kralj, Marijeta; Piantanida, Ivo
Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives // New journal of chemistry, 34 (2010), 3; 500-507 doi:10.1039/b9nj00490d (međunarodna recenzija, članak, znanstveni)
Radić Stojković, M., Marjanović, M., Pawlica, D., Dudek, L., Eilmes, J., Kralj, M. & Piantanida, I. (2010) Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives. New journal of chemistry, 34 (3), 500-507 doi:10.1039/b9nj00490d.
@article{article, author = {Radi\'{c} Stojkovi\'{c}, Marijana and Marjanovi\'{c}, Marko and Pawlica, Dariusz and Dudek, Lukasz and Eilmes, Julita and Kralj, Marijeta and Piantanida, Ivo}, year = {2010}, pages = {500-507}, DOI = {10.1039/b9nj00490d}, keywords = {dibenzotetraaza[14]annulene, DNA and RNA polynucleotides, spectrophotometric titrations, antiproliferative activity, tumour cell lines}, journal = {New journal of chemistry}, doi = {10.1039/b9nj00490d}, volume = {34}, number = {3}, issn = {1144-0546}, title = {Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives}, keyword = {dibenzotetraaza[14]annulene, DNA and RNA polynucleotides, spectrophotometric titrations, antiproliferative activity, tumour cell lines} }
@article{article, author = {Radi\'{c} Stojkovi\'{c}, Marijana and Marjanovi\'{c}, Marko and Pawlica, Dariusz and Dudek, Lukasz and Eilmes, Julita and Kralj, Marijeta and Piantanida, Ivo}, year = {2010}, pages = {500-507}, DOI = {10.1039/b9nj00490d}, keywords = {dibenzotetraaza[14]annulene, DNA and RNA polynucleotides, spectrophotometric titrations, antiproliferative activity, tumour cell lines}, journal = {New journal of chemistry}, doi = {10.1039/b9nj00490d}, volume = {34}, number = {3}, issn = {1144-0546}, title = {Cationic side-chains control DNA/RNA binding properties and antiproliferative activity of dicationic dibenzotetraaza[14]annulene derivatives}, keyword = {dibenzotetraaza[14]annulene, DNA and RNA polynucleotides, spectrophotometric titrations, antiproliferative activity, tumour cell lines} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus

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