Naslov
Serum creatinine, urea nitrogen and hematocrite in the early detection of pancreatic necrosis

Autori
Poropat, Goran ; Hauser, Goran ; Licul, Vanja ; Štimac, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Gut / - , 2009, A238-A238

Skup
Gastro 2009 - UEGW/WCOG

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 21.11.2009. - 26.11.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Creatinine; urea nitrogen; hematocrite; acute pancreatitis; severity

Sažetak
INTRODUCTION: Pancreatic necrosis is a serious local complication of acute pancreatitis associated with worse clinical outcome and higher mortality. AIMS & METHODS: The main focus of our study was to identify predictive value of serum creatinine, urea nitrogen and hematocrit in early detection of pancreatic necrosis in patients with acute pancreatitis.We analyzed 97 patients with moderate to severe acute pancreatitis defined by an APACHE II score of 6 and more. All subjects performed computerized tomography (CT) between days 4 and 7 of admission with the calculation of CTSI score. Values of serum creatinine, urea nitrogen and hematocrit were assessed on admission and on days 2 and 3. We calculated the intravenous fluid resuscitation volume for each patient on admission and within 72 h of admission. RESULTS: Of 97 included patients, 24 (25%) developed pancreatic necrosis. Low serum hematocrit on admission showed a negative predictive value of 82%, while no significant results were obtained for serum creatinine and urea nitrogen. ROC curves for pancreatic necrosis revealed an area under the curve of 0.67 for admission hematocrit, 0.44 for peak creatinine, and 0.48 for peak urea nitrogen. Binary logistic regression retrieved no significant association between the three tests and pancreatic necrosis. We found that patients who developed pancreatic necrosis received a significantly higher volume of intravenous fluid resuscitation within the first 24 h (P<0.005). CONCLUSION: We confirmed that a low admission hematocrit is associated with a low incidence of pancreatic necrosis. Our results don't suggest significant association of serum creatinine and urea nitrogen values with the development of pancreatic necrosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA