Naslov
Brainstem raphe alteration in depressed and suicidal patients recorded on transcranial sonography (TCS)

Autori
Budišić, Mislav ; Crnjaković, Miljenko ; Karlović, Dalibor ; Trkanjec, Zlatko ; Lovrenčić-Huzjan, Arijana ; Vuković, Vlasta ; Bene, Raphael ; Demarin, Vida

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Journal of the Neurological Sciences, Vol.285, Suppl.1 / Lisak, R.P. - : Elsevier, 2009

Skup
19th World Congress of Neurology

Mjesto i datum
Bangkok, Tajland, 24.10.2009. - 30.10.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
raphe; transcranial sonography; TCS; depressed; suicidal

Sažetak
Purpose: Depletion of monoamine serotonin and dopamine system is a frequent finding in the depressive state and deficient levels of serotonin are associated with suicide and depression. Recent transcranial sonography (TCS) studies showed that disruption of echogenic midbrain line corresponding to nuclei raphe might represent functional marker for the development of depression. We initiated this study to asses usefulness of TCS recording in a group of major depressed patients (MDD) and in MDD patients who reported suicidal ideation, on the assumption that TCS might serve as a screening method for differentiating patients at risk of suicide. Patients and Methods: Thirty six patients with MDD (DSM-IV) of whom 16 were suicidal and 30 controls where studied using TCS. Severity of the disease was measured according to Hamilton Depression Rating Scale (HDRS) Examination was performed by standardized semiquantative protocol by two independent physicians. Results: Reduced raphe echogenicity was found in 23 of 36 (64%) of the patients with unipolar depression but only in 3 (10%) controls. Furthermore, 13 of 16 (81%) suicidal patients exhibit same reduced echogenicity, what was also in negative correlation with the severity of the illness assessed by HDRS cc = −0.569, p = 0.003. No correlation was found between raphe echogenicity and number of depressive episodes, age, gender or duration of the disease. (p < 0.05). Interobserver reliability for this method was significant. Discussion: Our results showed that alteration of raphe nuclei is frequent TCS finding in depressive states. That finding is rare in healthy subjects, however, in suicidal patients such alteration was even more pronounced. These data suggest that TCS might be novel method for the detection of depressive disorders and might record patients with suicidal risk within.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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