Naslov
ABC transport proteins as mediators of the multixenobiotic resistance (MXR) defence mechanism in aquatic organisms

Autori
Sauerborn Klobučar, Roberta ; Žaja, Roko ; Smital, Tvrtko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 2005 FEBS Forum for Young Scientists and 30th FEBS Congress and the 9th IUBMB Conference on the Protein World ; u: FEBS Journal 272 (2005) (S1) ; C2-021P / - Budimpešta : Blackwell Publishing, 2005

Skup
FEBS Forum for Young Scientists ; 30th FEBS Congress (30 ; 2005) ; IUBMB Conference on the Protein World (9 ; 2005)

Mjesto i datum
Budimpešta, Mađarska, 30.06.2005. - 07.07.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MXR mehanizam; ABC transportni proteini; vodeni organizmi
(MXR mechanism; ABC transport proteins; aquatic organisms)

Sažetak
One of the most intriguing cellular defence strategies evolutionary developed in aquatic organisms is the activity of the multixenobiotic resistance (MXR) mechanism first described in early 1990s by Kurelec and co-workers. Analogous to the well-known multidrug resistant (MDR) mechanism, MXR in aquatic organisms is mediated by expression of the same transmembrane ATP-dependent proteins. MDR/MXR results from the rapid efflux of a wide variety of potentially toxic xenobiotics out of the cell. The best-studied ABC protein in aquatic organisms is the P-glycoprotein, while our recent studies demonstrate the presence of the MRP-related genes in fish and some non-vertebrate species. Numerous studies performed during the last decade support the proposed MXR role as a general, broadly distributed biological system in aquatic organisms used as a “first line of defense” against endogenous and exogenous toxins. However, recently demonstrated environmental presence of the so-called chemosensitizers or inhibitors of the MXR defense in aquatic organisms could cause increase in intracellular accumulation and toxic effects of other xenobiotics normally effluxed by MXR transport proteins. As a consequence, within the field of ecotoxicology there is an increasing interest for better characterization and identification of all proteins possibly involved in MXR phenomenon and our intention is to stimulate a more efficient and fruitful collaboration between ecotoxicologists and experts for ABC transport proteins.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA