Naslov
Applicability of RP-TLC method for the assessment of lipophilicity of beta-lactams used in treatment of CNS infections

Autori
Bojić, Mirza ; Mirat, Alemka ; Medić-Šarić, Marica ; Rajić, Zrinka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Pharmaceutical Sciences, Supplement: 3rd BBBB-Bosporus International Conference on Pharmaceutical Sciences / Hincal, Atilla ; Celebi, Nevin ; Yuksel, Nilufer - : Elsevier, 2009, 196-197

Skup
3rd BBBB-Bosporus International Conference on Pharmaceutical Sciences

Mjesto i datum
Antalya, Turska, 26.10.2009. - 28.10.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
RP-TLC; lipophilicity; beta-lactams

Sažetak
80 years have passed since Fleming published discovery of penicillin. Beta-lactams have been for years the safest and most efficient antibiotics owing it to the specific action on bacterial cell wall. Nowadays, beta-lactams are in their renaissance as multipotent agents against neurological diseases (e.g. amylotrophic lateral sclerosis, Alzheimer, Parkinson and prion diseases). Thus their lipophilicity, as major characteristic determining passage through blood-brain barrier, is of grate importance for their targeted delivery. As TLC is relatively inexpensive and time saving method we decided to characterise each beta-lactam with chromatographic parameters RM0 and φ 0 using linear solvent strength model. Although LSS models for other beta- lactams were suitable, RP-TLC should be used as indicative rather than quantitative measurement for characterisation of lipophilicity of beta-lactams in methanol-water systems.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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