Naslov
Lamotrigine therapy for resistant pain in radicular lesions of cervical segments C4-C5 and C5-C6: a case report

Autori
Titlić, Marina ; Jukić, Ivana ; Tonkić, Ante ; Buča, Ante ; Aleksić-Shihabi, Anka

Izvornik
Acta clinica Croatica (0353-9466) 48 (2009), 2; 157-160

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, znanstveni

Ključne riječi
spinal cord disease ; therapy ; neuralgia physiopathology ; neuralgia ; drug therapy ; anticonvulsants ; pharmacology ; pain ; drug therapy

Sažetak
Radicular pain syndromes caused b< disk herniation are often accompanied b< incomplete cental cord syndrome. Intensiv epain is difficult to control with standard analgesics. Antiepileptics of new generation have shown significant efficacy in treating pain syndromes, trigeminal neuralgia, diabetic neuropathy, migraines, etc. The treatment of radicular pain with lamotrigine, a new generation antiepileptic, turned out to be effective in lumbar disk radicular conflicts, justigying its application for resistant pain in cervical segment. In our patient, pain intensity was signficantly reduced with gradual titration of lamotrigine to a dose of 200 mg/da<. Pain intensity measurd by the visual analog scale significantly decreased from 100 to 20 mm during eight weeks of titration. The blood concentration of the drug measured b< the method of high performance liquid chromatography was 13.65 umol/l. The patients quality of life improved greatly. It is necessary to further evaluate the efficacy of lamotrigine in the treatment of resistant radicular damage.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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