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Pregled bibliografske jedinice broj: 429177

Synthesis and evaluation of novel analogues of vitamine B6 as reactivators of tabun- and paraoxon-inhibited acetylcholinesterase

Gašo-Sokač, Dajana; Katalinić, Maja; Kovarik, Zrinka; Bušić, Valentina; Kovač, Spomenka
Synthesis and evaluation of novel analogues of vitamine B6 as reactivators of tabun- and paraoxon-inhibited acetylcholinesterase // 10th International Meeting on Cholinesterases, Šibenik, Hrvatska, Programme and Abstracts / Kovarik, Zrinka (ur.).
Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2009. str. 96-97 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 429177 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis and evaluation of novel analogues of vitamine B6 as reactivators of tabun- and paraoxon-inhibited acetylcholinesterase
(Synthesis and evaluation of novel analoges of vitamine B6 as reactivators of tabun - and paraoxon-inhibited acetylcholinesterase)

Autori
Gašo-Sokač, Dajana ; Katalinić, Maja ; Kovarik, Zrinka ; Bušić, Valentina ; Kovač, Spomenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
10th International Meeting on Cholinesterases, Šibenik, Hrvatska, Programme and Abstracts / Kovarik, Zrinka - Zagreb : Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2009, 96-97

ISBN
978-953-95551-3-7

Skup
10th International Meeting on Cholinesterases

Mjesto i datum
Šibenik, Hrvatska, 20.09.2009. - 25.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
pyridoxal oxime ; reactivation ; acetylcholinesterase ; tabun ; paraoxon
(pyridoxal oxime ; reactivation ; acetylcholinesterase ; tabun)

Sažetak
A series of novel pyridinium oximes were prepared by reactions of quaternization of pyridoxal oxime with substituted phenacyl bromides in acetone at room temperature and methanol with refluxing. The structures of compounds were determined according to the data obtained by IR-spectroscopy, 1H- and 13C- nuclearmagnetic resonance as well as by elemental analysis. We tested five oximes in 1 mM concentration as reactivators of human erythrocytes acetylcholinesterase (AChE) inhibited by organophosphorus compounds tabun and paraoxon: 1-phenacyl-3-hydroxy-4- hydroxyiminomethyl-5-hydroxymethyl-2- methylpyridinium bromide, 1-(4’ - chlorophenacyl)-3-hydroxy-4-hydroxyiminomethyl- 5-hydroxymethyl-2-methylpyridinium bromide, 1- (4’ -fluorophenacyl)-3-hydroxy-4- hydroxyiminomethyl-5-hydroxymethyl-2- methylpyridinium bromide, 3-hydroxy-4- hydroxyiminomethyl-5-hydroxymethyl-2-methyl-1- (4’ -methylphenacyl) pyridinium bromide, 3- hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2- methyl-1-(4’ -methoxyphenacyl) pyridinium bromide. However, tested oximes were not efficient in reactivation of both tabun and paraoxon inhibited AChE. The maximum restored enzyme activity in 24 h was below 25 %.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
022-0222148-2889 - Interakcije organofosfata, karbamata i određenih liganada s esterazama (Kovarik, Zrinka, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Prehrambeno-tehnološki fakultet, Osijek

Profili:

Avatar Url Valentina Bušić (autor)

Avatar Url Maja Katalinić (autor)

Avatar Url Dajana Gašo-Sokač (autor)

Avatar Url Spomenka Kovač (autor)

Avatar Url Zrinka Kovarik (autor)

Citiraj ovu publikaciju:

Gašo-Sokač, Dajana; Katalinić, Maja; Kovarik, Zrinka; Bušić, Valentina; Kovač, Spomenka
Synthesis and evaluation of novel analogues of vitamine B6 as reactivators of tabun- and paraoxon-inhibited acetylcholinesterase // 10th International Meeting on Cholinesterases, Šibenik, Hrvatska, Programme and Abstracts / Kovarik, Zrinka (ur.).
Zagreb: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2009. str. 96-97 (poster, međunarodna recenzija, sažetak, znanstveni)
Gašo-Sokač, D., Katalinić, M., Kovarik, Z., Bušić, V. & Kovač, S. (2009) Synthesis and evaluation of novel analogues of vitamine B6 as reactivators of tabun- and paraoxon-inhibited acetylcholinesterase. U: Kovarik, Z. (ur.)10th International Meeting on Cholinesterases, Šibenik, Hrvatska, Programme and Abstracts.
@article{article, author = {Ga\v{s}o-Soka\v{c}, Dajana and Katalini\'{c}, Maja and Kovarik, Zrinka and Bu\v{s}i\'{c}, Valentina and Kova\v{c}, Spomenka}, editor = {Kovarik, Z.}, year = {2009}, pages = {96-97}, keywords = {pyridoxal oxime, reactivation, acetylcholinesterase, tabun, paraoxon}, isbn = {978-953-95551-3-7}, title = {Synthesis and evaluation of novel analogues of vitamine B6 as reactivators of tabun- and paraoxon-inhibited acetylcholinesterase}, keyword = {pyridoxal oxime, reactivation, acetylcholinesterase, tabun, paraoxon}, publisher = {Hrvatsko dru\v{s}tvo za biokemiju i molekularnu biologiju (HDBMB)}, publisherplace = {\v{S}ibenik, Hrvatska} }
@article{article, author = {Ga\v{s}o-Soka\v{c}, Dajana and Katalini\'{c}, Maja and Kovarik, Zrinka and Bu\v{s}i\'{c}, Valentina and Kova\v{c}, Spomenka}, editor = {Kovarik, Z.}, year = {2009}, pages = {96-97}, keywords = {pyridoxal oxime, reactivation, acetylcholinesterase, tabun}, isbn = {978-953-95551-3-7}, title = {Synthesis and evaluation of novel analoges of vitamine B6 as reactivators of tabun - and paraoxon-inhibited acetylcholinesterase}, keyword = {pyridoxal oxime, reactivation, acetylcholinesterase, tabun}, publisher = {Hrvatsko dru\v{s}tvo za biokemiju i molekularnu biologiju (HDBMB)}, publisherplace = {\v{S}ibenik, Hrvatska} }

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