Naslov
Methemoglobin as The Biomarker Of Environmental Oxidants And Precursor Of Adverse Effcts Of Oxidative Stress On Mother And Fetus- Reasons For Its Early Detection And Therapy

Autori
Mohorović, Lucijan ; Matturri L.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book of the Second World Conference on Magic Bullets (Ehrlich II) / - , 2008, A-216

Skup
World Conference on Magic Bullets (Ehrlich 2 ; 2008)

Mjesto i datum
Nürnberg, Njemačka, 03.10.2008. - 05.10.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
methemoglobin; environmental oxidants

Sažetak
Methemoglobin (MetHb) and its catabolic products are prooxidant. In the first blood circulation stage, the inhalation of nitrogen oxides transforms the hemoglobin into its pathological MetHb. Methemoglobinemia symptoms in "maternal preeclampsia" are also common in severe anemia, preeclampsia and eclampsia, suggesting them to be a precursor for these conditions. The oxidants crossing the placental barrier cause "fetal preeclampsia". The levels of MetHb and its catabolic products as bilirubin-biliverdin, CO and toxic Fe (III) with paramagnetic nature probably go over to BBB and provoke adverse effects on brain development. The objective is to confirm the anatomo-pathological and genetic alterations that underlie sudden unexpected and unexplained perinatal and infant death and their correlation with environmental factors. The MetHb level was determined from the samples that were taken three times, with a one-month pause between each test, for each pregnant woman (N=122) in the exposure period of power plant operation and in the control period when the power plant was closed (N=138). The significant positive correlation between the level of MetHb and the daily ground level concentration of SO2 was found (r=0.72, p<0.01). The reproductive loss was significant between the >control< (N=4) and >exposure< periods (N=10) (p=0.0369) and the frequency of stillbirths with the amount of MetHb >1.5 g/L in the exposure period was also statistically significant (p=0.0336). The test of chromosome aberration (SCI) was not significant in newborns whose mothers' MetHb level was >1.5 g/L (N=36). We observed them by collecting data from hospitals, preschool and school services at health centers until they were eighteen years of age, and we found that the incidences of neonatal jaundice (p=0.034), later heart murmur (p=0.011) and dyslalia and learning / memory impairments (p=0.002) were significantly higher than in children born by control mothers (n=19). The MetHb level is a useful biomarker but also has a degree of predictive validity. Our current research intends to study the brain morphological aspects of the development of both the autonomic nervous system and the cardiac conduction system and to individuate the environmental interactions resulting in the perinatal unexplained death, as well as to help find therapy, especially in underdeveloped countries with high maternal and perinatal morbidity and mortality.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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