Naslov
The Role of CD4 and CD8 Lymphocytes and Macrophages in Psoriasis Vulgaris

Autori
Čabrijan, Leo ; Lipozenčić, Jasna ; Batinac, Tanja ; Peternel, Sandra ; Paštar, Zrinjka

Izvornik
Acta dermatovenerologica Croatica (1330-027X) 17 (2009), 3; 162-165

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CD4; CD8; macrophages; psoriasis vulgaris

Sažetak
Current knowledge of the immunopathogenesis of psoriasis vulgaris is based on the crucial role of CD4 and CD8 lymphocytes. Also, the connection of activated lymphocytes with macrophages, especially dendritic cells and plasmacytoid dendritic cells, is considered to be significant. In the present study, the expression of CD4+ lymphocytes as well as CD8+ lymphocytes (P<0.001) and macrophages (P<0.001) was found to be significantly increased in lesional skin epidermis and dermis in psoriasis vulgaris patients as compared with healthy skin. These findings suggested a cascade or chain reaction with cells and cytokines playing an important role to be involved in the immunopathogenesis of psoriasis vulgaris.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA