Naslov
Changing pattern of acute poisoning with psychoactive drugs in Croatia

Autori
Macan, Jelena ; Turk, Rajka ; Plavec, Davor ; Bošan-Kilibarda, Ingrid

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 51 (2000), 4; 381-387

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Poison Control Centre; benzodiazepines; neuroleptics; antidepressants; amytriptyline

Sažetak
The aim of this study was to analyse the frequency of acute poisoning with psychoactive drugs (benzodiazepines, antidepressants and neuroleptics) during the last 15 years in Croatia. Data were collected from the national Poison Control Center in Zagreb, with respect to all phone calls related to the drug ingestions. Drug ingestions were analysed in two time intervals: period I (1985.-1991.) and period II (1992.-1999.), separately in children and adults. Each phone call was counted as one poisoning incident, including multiple poisoning (ingestion of more then one drug at the same time). In children, only the frequency of acute poisoning with neuroleptics was significantly higher in period II than in period I (7.4%:4.4% P<0.05). The frequency of adult poisoning with antidepressants and amytriptyline alone was significantly higher in period II than in period I (antidepressants – 13.0%:5.9% P<0.01; amytriptyline- 7.3%:2.9% P<0.05), as well as the frequency of multiple psychoactive drug poisoning (45.3%: 29.1% P<0.01). In both time periods, the frequency of total psychoactive drug poisoning was significantly higher in adults then in children (period I – 53.9%: 19.4% P<0.01; period II – 61.3%:19.1% P<0.01). From 1992. number of acute poisoning with antidepressants among adults in Croatia is considerably increasing as one of the many consequences of war related population stress. Results indicate a need for careful psychiatric evaluation and more critical use of antidepressants in affected individuals.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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