Naslov
Pathogenesis of murine cytomegalovirus infection in neonatal mice

Autori
Trgovcich, Joanne ; Pernjak-Pugel, Ester ; Tomac, Jelena ; Koszinowski, Ulrich H. ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
CMV-Related Immunopathology : 1st International Consensus Round Table Meeting / Scholz, M. ; Rabenau, H.F. ; Doerr, H.W. ; Cinatl, J.Jr. - Basel : Karger Publishers, 1998, 42-53

ISBN
3-8055-6602-5

Skup
International Consensus Round Table Meeting 81 ; 1997)

Mjesto i datum
Frankfurt na Majni, Njemačka, 08.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
perinatal infection; cytomegalovirus; cytokines; immunosurveillance; immunopathology

Sažetak
These findings underscore the utility of the mouse model in investigation of cytomegalovirus pathogenesis in infants. Although congenital transmission does not occur in mice, postnatal infection of neonatal mice reproduces many of the important findings in humans. Furthermore, these studies have highlighted numerous issues, which have yet to be addressed. For example, what is the nature and what are the long-term consequences of virus replication in the bone marrow, CNS and other tissues ; what is the nature of the immune response and role of immune responses in contributing both to virus clearance and pathogenetical changes ; and does virus infection induce chronic or self-limiting inflammatory responses? Furthermore, the finding that the virulence of WT virus is linked to induction of potentially toxic levels of TNF-a represents a previously unrecognized aspect of MCMV pathogenesis. The role of this and other cytokines which may be upregulated during infection are yet to be elucidated. Finally, this model may be particularly important in investigating the basic biology of CMV, including elucidating the roles of viral virulence determinants, such as the fcr gene product, in this virus infection.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Monographs in Virology ; Vol. 21 ; ISSN 0077-0965

POVEZANOST RADA