Pregled bibliografske jedinice broj: 427408
First two months of pregnancy--critical time for preterm delivery and low birthweight caused by adverse effects of coal combustion toxics
First two months of pregnancy--critical time for preterm delivery and low birthweight caused by adverse effects of coal combustion toxics // Early Human Development, 80 (2004), 2; 115-123 doi:10.1016/j.earlhumdev.2004.06.001 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 427408 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
First two months of pregnancy--critical time for preterm delivery and low birthweight caused by adverse effects of coal combustion toxics
Autori
Mohorović, Lucijan
Izvornik
Early Human Development (0378-3782) 80
(2004), 2;
115-123
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Critical windows of exposure; Methemoglobin; Mother hypoxemia– hypoxia; Preterm delivery; Low birthweight; Environmental toxics; Sulfur dioxide; Nitrogen dioxide; Coal combustion products
Sažetak
Objective The objective of this study was to define the most critical gestation period for adverse effects of environmental toxics in terms of preterm delivery (<37 weeks) and low birthweight (<2500 g) in humans. Study design From January 1, 1987 to December 31, 1989, 704 women were included in a retrospective epidemiological study. All were from the district of Labin and lived in the vicinity of a coal power plant Plomin 1, Croatia. This plant is the single large source of air pollution in the area. The coal used for fuel is extremely rich with sulfur, 9– 11%. Daily, weekly, and monthly consumption of coal and related SO2 emissions were calculated for each pregnant woman from the beginning to the end of pregnancy. Results We found that a greater and longer exposure to SO2 emissions during the initial two months of pregnancy resulted in a significantly shorter gestation (end of the first month: − 0.0914, p=0.008, end of the second month: − 0.0806, p=0.016) and in lower body mass of a newborn (end of the first month: − 0.0807, p=0.016, end of the second month − 0.0733, p=0.026). Conclusion The results of this study confirm the role of inhaled environmental toxics in the early development of human embryo and in adverse pregnancy course caused by permanent oxidative stress, misbalanced production of reactive oxygen species (ROS), reactive nitrogen species (RNS), reactive sulfur species (RSS), and other unfavorable metabolic processes on early embryogenesis, resulting in growth-arrested cells.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
