Naslov
Anxiety-related behavior in rats with constitutionally altered serotonergic activity

Autori
Mokrović, Gordana ; Čičin-Šain, Lipa

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta Neurobiologiae Experimentalis / - , 2009, 368-368

Skup
9th International Congress of the Polish Neuroscience Society

Mjesto i datum
Varšava, Poljska, 09.09.2009. - 12.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
serotonin; Wistar-Zagreb 5HT rat; anxiety; behavior

Sažetak
Serotonin (5HT, 5-hydroxytryptamine) is involved in regulation of both central and peripheral physiological functions, and disturbances in serotonergic neurotransmission are common in neuropsychiatric disorders. Using selective breeding, we have developed Wistar-Zagreb 5HT rats that include two sublines: one with high (high-5HT) and other with low (low-5HT) levels of peripheral (platelet) serotonin and activity of 5HT transporter, representing a rodent model with constitutionally altered serotonin homeostasis. We hypothesized that in these animals, beside peripheral, brain serotonergic activity is also altered which should have effect on their behavioral response. In the present study, we have tested the anxiety-related behavior of 5HT sublines (3 months old males, N=20-21 per subline) in elevated plus maze and open field paradigms. Animals from high-5HT subline had lower score in time spent in open arms and number of entries to the open arms of elevated plus maze in comparison to low-5HT subline (p<0.05). Also, the score of head dip time in open arms was lower in high-5HT subline (p<0.005). In open field test, high-5HT subline had lower score in total rearing time (p<0.005). Altogether, these results confirm results of previous behavioral tests (hole-board and zero maze) showing differences in anxiety-related behavior in Wistar-Zagreb 5HT rats and indicating higher level of anxiety-related behavior in high-5HT subline.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

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