Naslov
Chitosan-based mucoadhesive films with cyclodextrins as a novel delivery system for buccal application of bupivacaine

Autori
Jug, Mario ; Mura, Paola ; Maestrelli, Francesca ; Cirri, Marzia

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXI Simposio A.D.R.I.T.E.L.F. Veicolazione dei farmaci: aspetti technologici inovativi PROGRAMMA & ABSTRACTS Cagliari, 10-13 Settembre 2009 / Conte, Ubaldo - Cagliari : Universita degli Studi di Cagliari, 2009, PB 23-PB 23

Skup
XXI Simposio A.D.R.I.T.E.L.F.

Mjesto i datum
Cagliari, Italija, 10.09.2009. - 13.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
chitosan; cyclodextrin; bupivacaine; buccal delivery

Sažetak
Chitosan (CH) based mucoadhesive films may be suitable formulations to obtain a local delivery of bupivacaine hydrochloride (BVP), which can be beneficial in treatments of chronic inflammatory lesions of the oral mucosa. The drug release from such devices must be controlled in order to obtain prolonged analgesic action without systemic side-effects. To achieve this goal, suitable carriers such as cyclodextrins should be used. With this aim, we prepared mucoadhesive films using CH as a mucoadhesive compound and ß-cyclodextrin (ß-CD) or epichlorhydrin-ß-cyclodextrin polymer as drug release modulators. Possible interactions among the components used to formulate the films were assessed by thermal (DSC) and spectral (FTIR) analyses. The swelling properties of the prepared formulations and the in vitro drug release behaviour were determined simulating the conditions present at the surface of the buccal mucosa. DSC and FTIR analyses indicated the existence of solid-state interactions between CH and BVP, while EPI-ß-CD showed higher affinity than ß-CD for interaction with CH. The swelling behaviour of the CH film was limited, probably by in situ chitosan cross-linking with phosphate ions from the simulated saliva solution, thus controlling the drug release. The interaction of EPI-ß-CD with CH further decreased the swelling rate of the film, while unbounded ß-CD acted as a channelling agent improving the swelling of CH matrix. The contrasting effect of tested CDs on CH swelling rate and their different affinity for complexation with BVP (Ks for ß-CD and EPI-ß-CD are 21 and 83 M-1, respectively) resulted in diverse drug release behaviour from films.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA