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Pregled bibliografske jedinice broj: 426017

Increased expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in lichen planus lesions

Peternel, Sandra; Kaštelan, Marija; Prpić-Massari, Larisa; Kurilić, Marijana
Increased expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in lichen planus lesions // Journal of Investigative Dermatology, 2009 ; 129 (Supplement 2s)
Budimpešta, Mađarska: Nature publishing group, 2009. (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 426017 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Increased expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in lichen planus lesions

Autori
Peternel, Sandra ; Kaštelan, Marija ; Prpić-Massari, Larisa ; Kurilić, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Investigative Dermatology, 2009 ; 129 (Supplement 2s) / - : Nature publishing group, 2009

Skup
39th Annual ESDR Meeting

Mjesto i datum
Budimpešta, Mađarska, 09.09.2009. - 12.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
lichen planus; TNF-related apoptosis-inducing ligand; Death receptor 4; Death receptor 5

Sažetak
The hallmark pathohistological change in lichen planus lesions is damage to the epidermal basal layer, considered to be mediated by dermal mononuclear cell inflammatory infiltrate. The purpose of our study was to investigate whether this damage might be mediated by tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and its two death receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5). The pattern of tissue expression of TRAIL and its receptors was analyzed by immunohistochemical analysis performed on lesional skin samples of patients with lichen planus as well as skin samples of healthy volunteers. TRAIL and both of its receptors were found to be strongly expressed among cells comprising the dermal infiltrate in lesional skin. The epidermal expression of TRAIL was only slightly increased in lichen planus lesions when compared to healthy skin. Interestingly, a significantly stronger expression of DR4 and DR5 was observed in the epidermal basal layer of lichen planus lesions when compared to healthy skin in which the expression was low or even absent. These results indicate that TRAIL/DR4/DR5 -mediated signalling might be involved in the pathogenesis of lichen planus, especially in the basal cell layer degeneration typical of this dermatosis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
062-0620239-0197 - Imunološki mehanizmi u patogenezi psorijaze (Kaštelan, Marija, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Profili:

Avatar Url Marija Kaštelan (autor)

Avatar Url Sandra Peternel (autor)

Avatar Url Marijana Vičić (autor)

Avatar Url Larisa Prpić Massari (autor)

www.nature.com

Citiraj ovu publikaciju:

Peternel, Sandra; Kaštelan, Marija; Prpić-Massari, Larisa; Kurilić, Marijana
Increased expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in lichen planus lesions // Journal of Investigative Dermatology, 2009 ; 129 (Supplement 2s)
Budimpešta, Mađarska: Nature publishing group, 2009. (poster, međunarodna recenzija, sažetak, znanstveni)
Peternel, S., Kaštelan, M., Prpić-Massari, L. & Kurilić, M. (2009) Increased expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in lichen planus lesions. U: Journal of Investigative Dermatology, 2009 ; 129 (Supplement 2s).
@article{article, author = {Peternel, Sandra and Ka\v{s}telan, Marija and Prpi\'{c}-Massari, Larisa and Kurili\'{c}, Marijana}, year = {2009}, pages = {S95}, keywords = {lichen planus, TNF-related apoptosis-inducing ligand, Death receptor 4, Death receptor 5}, title = {Increased expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in lichen planus lesions}, keyword = {lichen planus, TNF-related apoptosis-inducing ligand, Death receptor 4, Death receptor 5}, publisher = {Nature publishing group}, publisherplace = {Budimpe\v{s}ta, Ma\djarska} }
@article{article, author = {Peternel, Sandra and Ka\v{s}telan, Marija and Prpi\'{c}-Massari, Larisa and Kurili\'{c}, Marijana}, year = {2009}, pages = {S95}, keywords = {lichen planus, TNF-related apoptosis-inducing ligand, Death receptor 4, Death receptor 5}, title = {Increased expression of tumor necrosis factor-related apoptosis inducing ligand and its receptors in lichen planus lesions}, keyword = {lichen planus, TNF-related apoptosis-inducing ligand, Death receptor 4, Death receptor 5}, publisher = {Nature publishing group}, publisherplace = {Budimpe\v{s}ta, Ma\djarska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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