Naslov
Regulatory effects of CD4 and CD8+ T lymphocytes on liver regeneration after partial hepatectomy in mice

Autori
Petković, Marija ; Ćuk, Mira ; Radošević-Stašić, Biserka ; Trobonjača, Zlatko ; Milin, Čedomila ; Verbanac, Donatella ; Dvornik, Štefica ; Ravlić-Gulan, Jagoda ; Muhvić, Damir ; Rukavina, Daniel

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
4th International Congress on the Immune Consequences of Trauma, Shock and Sepsis : Mechanisms and Therapeutic Approaches : Abstracts / Faist E - Bolonja : Monduzzi Editore, 1997, 515-520

Skup
4th International Congress on the Immune Consequences of Trauma, Shock and Sepsis : Mechanisms and Therapeutic Approaches

Mjesto i datum
München, Njemačka, 04.03.1997. - 08.03.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
liver regeneration; CD4 and/or CD8 depletion; hepatic DNA; RNA and proteins; mice

Sažetak
The consequences of in vivo depletion of CD4+and/or CD8+ T lymphocytes on regenerating liver after partial hepatectomy (pHx) and the effects of pHx on intact and depleted lymphatic tissue were analysed. The results showed that depletion of CD8 and CD4+CD8 T lymphocytes significantly augment the content of RNA and proteins in early phase of regenerating liver. Removal of CD4+CD8 cells translocated also the peak of protein synthesis from 2nd to 1st post-Hx day. On the other hand, pHx stimulated the recovery of CD4+cells in CD4 depleted mice and augmented the proportion of CD8+ cells in both, CD8 and CD4+CD8 depleted mice.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA