Naslov
Galectin-3 decreases in mice exposed to immobilization stress

Autori
Dumić, Jerka ; Barišić, Karmela ; Flögel, Mirna ; Lauc, Gordan

Izvornik
Stress (1025-3890) 3 (2000), 3; 241-246

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
stress ; galectin-3 ; immobiliation ; lectins

Sažetak
Using M3/38 monoclonal antibody we have analyzed effects of immobilization stress on the expression of galectin-3 in liver, spleen and peritoneal macrophages from adult RFM and C3H mice, as well as from aged C3H mice (total of 22 animals). In all analyzed tissues, immobilization stress caused a significant decrease in the expression of galectin-3, ranging from 14% to 47%. The decrease of galectin-3 was observed in both strains of mice, as well as in old animals. Moreover, the same range of decrease (approximately 50%) was observed when cells grown in vitro were exposed to subculturing, or heat-shock. Although the biological significance of this effect is not known, it is very interesting that a single episode of immobilization stress was sufficient to cause a significant decrease in galectin-3, implicating that this beta-galactoside-binding lectin might be involved in the physiological response to psychological stress.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

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