Naslov
RNA Interference as a New Tool in Therapeutics

Autori
Matokanović, Mirela ; Barišić, Karmela

Izvornik
Food technology and biotechnology (1330-9862) 47 (2009), 3; 229-235

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
RNA interference; small interfering RNA; off-target effects; therapeutics

Sažetak
The basic principle of RNA interference, a possible new therapeutic tool, involves destruction of messenger RNA upon interaction with homologous double-stranded RNA present in the cell cytoplasm. Studies have shown that both viral and non-viral small interfering RNA delivery methods and delivery of chemically synthesized small interfering RNAs to the cell can provide selective gene suppression through this mechanism, both in vitro and in vivo. Before becoming a functional therapeutic tool, there are a number of problems concerning RNA interference that should be solved. Major problems involve off- -target effects, insertional mutagenesis and malignant transformation, as well as problems of delivery methods and reduction of toxicity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

Napomena
Odabrani radovi sa skupa Congress of Croatian Society of Biochemistry and Molecular Biology, održanog od 17.-20.09.2008.g., Osijek, Hrvatska.

POVEZANOST RADA