Pregled bibliografske jedinice broj: 4252
Human decidualized endometrial T lymphocytes express reduced levels of cytoplasmic CD3zeta
Human decidualized endometrial T lymphocytes express reduced levels of cytoplasmic CD3zeta // Journal of Reproductive Immunology 34 (1997), 1 / Bilington, W.D. ; Johnson, P.M. ; Scott, J.R. (ur.).
Charlottesville (VA): Elsevier, 1997. str. 54-54 (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 4252 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Human decidualized endometrial T lymphocytes express reduced levels of cytoplasmic CD3zeta
Autori
Bedenicki, Ivica ; Christmas, Stephen E. ; Newton, Darren J. ; Flanagan, Brian F. ; Rukavina, Daniel ; Johnson, Peter M.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Journal of Reproductive Immunology 34 (1997), 1
/ Bilington, W.D. ; Johnson, P.M. ; Scott, J.R. - Charlottesville (VA) : Elsevier, 1997, 54-54
Skup
First International Conference on Experimental and Clinical Reproductive Immunobiology
Mjesto i datum
Charlottesville (VA), Sjedinjene Američke Države, 30.09.1997. - 03.10.1997
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
T lymphocytes; CD3 zeta; decidual lymphocytes
Sažetak
T lymphocytes comprise 5-10% of leukocytes in the human decidualized endometrium in pregnancy. The immunobiological function of these cells is unknown, but their T cell antigen receptor (TCR) has been reported to be downregulated in pregnancy. We have analyzed expression of cell cytoplasmic CD3zeta, a component of the TCR complex involved in intracellular signalling, in human first trimester decidual T cells using flow cytometric analysis of permeabilized cells. A mean of 75% of decidual T cells co-expressed cytoplasmic CD3zeta and cell surface CD3eta, which was not different from peripheral blood T cells (p<0.1). However, the levels of CD3zeta expression were significantly lower in decidual than peripheral T cells, assessed by mean fluorescence intensity (4.2 vs. 5.5 ; p<0.05), in the presence of higher levels of cell surface CD3eta (10.1 vs. 6.6 ; p<0.05). CD3zeta was not systemically downregulated since cytoplasmic CD3zeta levels did not differ significantly in peripheral blood T cells from pregnant women compared with non-pregnant controls (p<0.2). CD8+ T cells outnumber CD4+ T cells in decidua but the proportions of these two T cell subsets that expressed cytoplasmic CD3zeta were not significantly different. These results demonstrate that human decidual T cells locally downregulate CD3zeta, which may compromise their capacity for activation.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
