Naslov
N-TERMINAL PRO B-TYPE NATRIURETIC PEPTIDE (NT- proBNP), PREDICTING SURVIVAL IN INFANT SEPTIC PATIENTS: A CASE REPORT

Autori
Culej, Jelena ; Knezović, Ivica ; Marević, Sanja ; Laškaj, Renata, Sokolić, Božica ; Petres, Blanka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Clinical Chemistry and Laboratory Medicine, Issue S1 (Jun 2009) Supplement: EUROMEDLAB Innsbruck 2009, pp. S5 – S409 / - Innsbruck, 2009, S250-S250

Skup
18th IFCC – EFCC European Congress of Clinical Chemistry and Laboratory Medicine

Mjesto i datum
Innsbruck, Austrija, 07.07.2009. - 11.07.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
N-terminal pro B-type natriuretic peptide; sepsis; child

Sažetak
Background: N-terminal pro B-type natriuretic peptide (NTproBNP)was recognized as a marker of heart failure. But some researches showed its value in diagnosis of sepsis and predicting mortality. Methods: Levels of NT-proBNP were measured by Cardiac reader, Roche. Measurement range: 60 ng/L - 3000 ng/L. Results: Retrospectively, we tried to assess the usefulness of measuring NT-proBNP in predicting mortality of two infant patients. The first patient was a nine-months-old female infant with confirmed meningococcal sepsis, Glasgow coma score: 9. On the second day of admission, the level of NT-proBNP was higher than 3000 ng/L, with elevated level of hsCRP (159 mg/L). NT-proBNP was measured two more times and its levels decreased respectively 2053 ng/L and 299 ng/L. According to other results there was no organ failure. The second patient was a nine-months-old male infant, with Glasgow coma score 14, admitted with diagnosis of bronchitis caused by Mycoplasma pneumoniae. The patient had corrected aortic stenosis and during mild respiratory infection his condition worsened with heart decompensation, secondary pneumonia and sepsis. Levels of NT-proBNP were measured four times and in all measurements, the levels were >3000 ng/L. hsCRP levels were not so high, 11.6 mg/L and lower which indicates the possibility of a generalized viral infection that caused sepsis syndrome. Organ failure occurred in this patient resulting in lethal outcome. Conclusions: These two cases have shown that measuring NT-proBNP levels in infant patients can be useful in predicting mortality, which was previously described in some other larger studies.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA