Pregled bibliografske jedinice broj: 4211
Examination of genotoxicity of 1-(4-acetil-aminobenzenesulfonyl)-1a,2,6,6a-tetrahydro-1H,4H-/1,3/-dioxepino/5,6-b/azirine (PL 611)
Examination of genotoxicity of 1-(4-acetil-aminobenzenesulfonyl)-1a,2,6,6a-tetrahydro-1H,4H-/1,3/-dioxepino/5,6-b/azirine (PL 611) // Book of Abstract / Turnidge, John (ur.).
Sydney: International Society of Chemotherapy, 1997. (poster, nije recenziran, sažetak, znanstveni)
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Naslov
Examination of genotoxicity of 1-(4-acetil-aminobenzenesulfonyl)-1a,2,6,6a-tetrahydro-1H,4H-/1,3/-dioxepino/5,6-b/azirine (PL 611)
(Examination of genotoxicity of 1-(4-acetyl-aminobenzenesulfonyl)1a,2,6,6a-tetrahydro-1H,4H-/1,3/-dioxepino/5,6-b/azirine (PL 611))
Autori
Franekić, Jasna ; Dumić, Miljenko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Book of Abstract
/ Turnidge, John - Sydney : International Society of Chemotherapy, 1997
Skup
20th International Congress of Chemotherapy
Mjesto i datum
Sydney, Australija, 29.06.1997. - 03.07.1997
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
genotoksičnost; S. typhimurium; S. cerevisiae; PL 611
(genotoxicity; S. typhimurium; S. cerevisiae; PL 611)
Sažetak
1(4-Acetylaminobenzenesulfonyl)-1a,2,6,6a-tetrahydro-1H,4H-/1,3/-dioxepino/5,6-b/azirine (PL 611), is antihyperglycemic originated in Pliva. Genotoxic properties of the drug were investigated using Ames test. For detecting frameshift and base supstitution mutations we used Salmonella typhimurium (TA98, TA1538, TA100 and TA1535) with and without metabolic activation. On the other hand, the yeast Saccharomyces cerevisiae (strain D7) was chosen as the eukaryotic test system to evaluate the induction of gene conversion. The results obtained demonstrate that PL 611 no caused mutagneic and recombinogenic effects.
Izvorni jezik
Engleski
