Naslov
Non-MS autoimmune demyelination

Autori
Čikeš, Nada ; Bosnić, Dubravka ; Sentić, Mirna

Izvornik
Clinical neurology and neurosurgery (0303-8467) 110 (2008), 9; 905-912

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, stručni

Ključne riječi
Connective tissue diseases; Demyelinating autoimmune diseases; CNS; Multiple sclerosis; Progressive multifocal leukoencephalopathy; Differential diagnosis

Sažetak
Connective tissue diseases can be characterised by central nervous system (CNS) involvement, in some patients manifested by demyelination areas in the white matter of the brain and spinal cord, which are difficult to differentiate from multiple sclerosis (MS) and other demyelinating processes, such as transverse myelitis and optic neuritis. Demyelinating process may be the feature of nervous impairment in systemic lupus erythematosus, Behcet's disease (BD), Sjoegren's syndrome (SS), systemic sclerosis (SSc) or very rarely other systemic autoimmune diseases. An acute isolated neurological syndrome, as the most common symptom of MS can sometimes be the only feature or even first manifestation of nervous impairment in connective tissue disease, hence presenting the diagnostic problem. Although the white matter abnormalities seen by magnetic resonance imaging may be similar in non-MS autoimmune demyelination and MS, it is the most important diagnostic tool in the differential diagnosis of the mentioned conditions. Investigating the presence of various autoantibodies potentially involved in the pathogenesis of demyelinating lesions as well as cerebrospinal fluid (CSF) analysis can be helpful.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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