Naslov
The burden of HPV-related diseases

Autori
Skerlev, Mihael

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts of the International Conference: “ The value of HPV vaccine in prophylaxis of cervical cancer and other HPV - associated diseases” / S. Majewski, M. Sikorski - Varšava : Polish Society for HPV prevention, 2009, 11-12

Skup
International Conference: “ The value of HPV vaccine in prophylaxis of cervical cancer and other HPV - associated diseases”

Mjesto i datum
Varšava, Poljska, 27.03.2009. - 29.03.2009

Vrsta sudjelovanja
Plenarno

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
HPV; clinical variations; burden; HPV vaccine

Sažetak
Anogenital infections caused by Human papillomavirus (HPV) are the most frequently diagnosed sexually transmitted infections (STIs) of viral origin, and the HPV types associated with such lesions have been studied extensively during the last years. Anogenital warts (condylomata acuminata) are the most common lesions presented in men, however, during the last decade the other HPV-associated exaggerated lesions such as condylomata plana, penile, scrotal, and anal intraepithelial neoplasias, as well as the penile, urine bladder and prostate cancer have been studied a little bit more extensively. Consistent studies are still lacking for male population. The clinical variations might range from clinically “ invisible” , “ asymptomatic” lesions to the bizarre forms of giant condyloma of Buschke-Löwenstein type, including Bowenoid papulosis, Mb. Bowen, different kinds of eryhtroplasias in both men and women and a large spectrum of HPV-induced dermatovenereological entities in genital region (not to speak about the other “ non-genital” HPV-associated diseases!). More than 35 types of HPV infect the genital tract ; types 16 and 18 inducing about 70% of high-grade intraepithelial genital neoplasias, such as penile, anal, scrotal, vulvar, vaginal etc. (thus not only cervical), and HPV 6 and 11 causing 90% of anogenital warts. However, the “ banality” of anogenital warts should not be underestimated providing that the high risk HPV DNA 16 and 18 can be isolated (PCR) from “ benign" HPV-associated genital lesions (anogenital warts) in 10-20% of patients, i.e. more than it is usually expected. On the other hand, the presence and the recalcitrant course of HPV DNA 6 and 11 associated diseases represent a significant physical and psychological problem for both men and women. A prophylactic vaccine that targets these types should thus substantially reduce the burden of HPV-associated clinical diseases. Ultimately, within the spectrum of therapeutic options for condylomata, no method is really superior to others ; recurrences occurred in 30-70% of cases. We definitely need the HPV vaccination programme to get rid of one of the oldest and up to now unsolved problems of mankind. Since HPV is transmitted by sexual intercourse, managing both partners is necessary in order to eliminate the virus in the population. Approaches to this include prophylactic vaccines such as quadrivalent HPV vaccine for both men and women. This should be the only way to significantly decrease the numbers of infected persons. Therefore, the diagnostic, therapeutic and prophylactic approach to HPV genital infections in both men and women needs to be complex. It can be thus concluded that, in this very moment, there is a need for a coordinated effort of patients, parents, health professionals, hospitals, and policymakers to ensure successful implementation of vaccination programs for both women and men.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Napomena
Svjetski skup (cca 400 sudionika) na temu HPV-genitalnih infekcija ; sadržajno - isključivo 12 pozivnih predavanja.

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