Pregled bibliografske jedinice broj: 417873
Principle of determining renin and aldosterone concentration and sample collecting
Principle of determining renin and aldosterone concentration and sample collecting // 4th Annual Meeting of the Croatian Society of Nuclear Medicine Technologists with International Participation "Nephrology in Nuclear Medicine"
Kraljevica, Hrvatska, 2009. (poster, međunarodna recenzija, sažetak, ostalo)
CROSBI ID: 417873 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Principle of determining renin and aldosterone concentration and sample collecting
Autori
Šalić, Ines ; Vrcelj, Marija ; Kosović, Pašezada ; Gardašanić, Jasna ; Marijanović, Vesna ; Mihaljević, Ivan
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo
Skup
4th Annual Meeting of the Croatian Society of Nuclear Medicine Technologists with International Participation "Nephrology in Nuclear Medicine"
Mjesto i datum
Kraljevica, Hrvatska, 22.05.2009. - 24.05.2009
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
captopril test; metods of collecting samples; renin
Sažetak
Renin is a proteolytic anzyme that affects angiotensin triggering a series of biochemical cascade reactions that lead to the generation of angiotensin II which is a strong vasoactive substance. Renin is dissolved from a nonactive prorenin generated and accumulated in granules of iuxtaglomerular renal cells. Angiotensin II affects directly smooth blood vessels causing vasoconstriction, and it also has an affect on increased aldosterone and catecholamine secretion from adrenal glands. In the physiological conditions the primary role of the renin-angiotensin-aldosterone system (RASS) is to regulate the blood pressure and salt and water matabolism. In the Department of Radiofarmacy and Radioimmunology of the Clinical Institute of Nuclear Medicine and Radiation Protection, Clinical Hospital Osijek, the blood samples are taken from hospitalized and ambulatory patients who underwent the captopril test and/or vein renal catetherization to determine renin and aldosterone concentration. Metods of collecting blood samples and determining renin and aldosterone activities are presented in the paper. The measurement of the plasma renin activity and the serum aldosterone concentration is performed by a radioimunological method (RIA) based on the competition between aldosterone and renin in blood sample and an antibody from a test tube. The plasma concentration renin is measured indirectly by determining angiotensin I concentrations that develope during in vitro incubation. We can conclude that this noninvasive method proved to be very useful for screening of different forms of renovascular hypertensions.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
