Naslov
The impact of surgery on neutrophil activity in patients with primary colonic malignancy - pilot study

Autori
Ratkajec, Valentina ; Stipančić, Igor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of The 44th Congress of the European Society for Surgical Research : ESSR Abstracts 2009 ; u: British Journal of Surgery 96 (2009) (S5) 1– 72 ; P1c-17 / - , 2009, 56-56

Skup
Congress of the European Society for Surgical Research (44 ; 2009)

Mjesto i datum
Francuska, 20.05.2009. - 23.05.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
colorectal cancer; surgery; neutrophil activity; respiratory burst; free radicals

Sažetak
Neutrophils produce free radicals and proteases and there are evidences that they could cause tumour cytolysis, support tumour cell invasion as well as promote tumour growth and metastasis. In cancer patients, perioperative and postoperative immunosuppression could accelerate the tumour growth and metastasis of residual tumour cells, thus adversely affecting the prognosis. Aims of our research are to determine and compare neutrophil activity in patients with colon cancer and healthy volunteers, to determine an effect of surgery on neutrophil activity and to elucidate the relationship between neutrophil activity and clinicopathologic status of disease. Respiratory burst neutrophil production was determined quantitatively by flow cytometry (Bursttest) in 15 patients with histolohically proven colon cancer submitted to elective radical surgery and compared to 15 healthy volunteers. Postoperative values of mean fluorescence intensity (MFE) of neutrophils having produced reactive oxygen metabolites were higher than preoperative values. When compared to healthy controls preoperative values were higher in patients with colorectal cancer. If the number of neutrophils in peripheral blood mirrors the situation in the tumor tissue, these data could support the investigation of neutrophil-targeted therapies in anti-cancer strategy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA