Pregled bibliografske jedinice broj: 41190
Soluble interleukin-6 receptor (sIL-6R) levels in the cerebrospinal fluid and serum of patients with multiple sclerosis.
Soluble interleukin-6 receptor (sIL-6R) levels in the cerebrospinal fluid and serum of patients with multiple sclerosis. // Revue Neurologique (Paris)2000 ; 156(Suppl.3): 3S88. / - (ur.).
Pariz: Masson, 2000. str. 3S88-3S88 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 41190 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Soluble interleukin-6 receptor (sIL-6R) levels in the cerebrospinal fluid and serum of patients with multiple sclerosis.
Autori
Vladić, Anton ; Šimaga, Šumski ; Horvat, Gordana ; Vukadin, Stjepan
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Revue Neurologique (Paris)2000 ; 156(Suppl.3): 3S88.
/ - Pariz : Masson, 2000, 3S88-3S88
Skup
ECTRIMS 2000 ; 16th Congress of the European Committee for Treatment and Research in Multiple Sclerosis
Mjesto i datum
Toulouse, Francuska, 06.09.2000. - 09.09.2000
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
interleukin-6 receptor; multiple screrosis; cerebrospinal fluid; human serum
Sažetak
Interleukin-6 (IL-6) is a proinflammatory cytokine which mediates cellular responses during inflammation and immune activation. Elevated levels of IL-6 are found in multiple sclerosis (MS) lesions and cerebrospinal fluid (CSF). This cytokine acts through IL-6 receptors. Soluble forms of these receptors are released from the cell surface and can be detected in CSF and serum. The aim of this study was to measure CSF and serum levels of sIL-6R (gp80) in patients with relapsing-remitting MS during exacerbations. We studied 20 patients with relapsing-remitting MS and 19 patients with non-inflammatory neurological diseases (NIND). In MS patients CSF and serum samples were obtained during exacerbations of the disease. Soluble IL-6R (gp80) in CSF and serum was measured by ELISA method, and values (median) were expressed in pg/mL. Low levels of sIL-6R were detected in the CSF of MS (950) and NIND (975) patients and were not significantly different. Serum sIL-6R levels were approximately 25-40 times higher than CSF levels in MS (28750) and NIND (35250) patients and were not significantly different. We found no significant difference in levels of sIL-6R in the CSF and serum between MS and NIND patients. Therefore, analysis of sIL-6R in the CSF and serum of relapsing-remitting MS patients is of limited value as a marker of disease activity.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
