Naslov
Beta-1 adrenoceptor antagonists potentiate the anticonvulsive effect of swim stress in mice

Autori
Peričić, Danka ; Jazvinšćak, Maja ; Švob, Dubravka ; Mirković, Kety

Izvornik
Pharmacology Biochemistry and Behavior (0091-3057) 67 (2000), 3; 507-510

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
swim stress; convulsions; mice; picrotoxin; propranolol; betaxolol; ICI 118; 551

Sažetak
To explore the possible involvement of beta adrenoceptor antagonists in the previously observed anticonvulsive effect of swim stress, the mice were, prior to administration of convulsants, pre-treated with propranolol (a non-selective beta adrenoceptor antagonist), betaxolol (a selective beta-1 adrenoreceptor antagonist), or ICI 118, 551 (a selective beta-2 adrenoreceptor antagonist). In control unstressed animals only propranolol (10 mg/kg i.p.) produced a significant change. It enhanced the threshold dose of picrotoxin producing tonic hindlimb extension. However, in swim stressed animals propranolol enhanced doses of picrotoxin producing tonic hindlimb extension and death, while betaxolol (20 mg/kg i.p.) enhanced doses of picrotoxin producing running/bouncing clonus, tonic hindlimb extension and death. Pre-treatment with ICI 118, 551 (4 mg/kg i.p.) failed to affect doses of picrotoxin producing convulsions and death. The results demonstrate that blockade of beta-1 adrenoceptors potentiates the anticonvulsant effect of swim stress against convulsions produced by picrotoxin, a noncompetitive GABAA receptor antagonist.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA