Pregled bibliografske jedinice broj: 41135
Combine and Free-Wilson QSAR analysis of nuclear receptor-DNA binding
Combine and Free-Wilson QSAR analysis of nuclear receptor-DNA binding // Molecular Modeling and Prediction of Bioactivity / Gudertofte, K ; Jorgensen, F. S. (ur.).
New York (NY): Kluwer Academic Publishers ; Plenum Publishers, 2000. str. 269-270
CROSBI ID: 41135 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Combine and Free-Wilson QSAR analysis of nuclear receptor-DNA binding
Autori
Tomić, Sanja ; Nillson, Lennart ; Wade, Rebecca
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni
Knjiga
Molecular Modeling and Prediction of Bioactivity
Urednik/ci
Gudertofte, K ; Jorgensen, F. S.
Izdavač
Kluwer Academic Publishers ; Plenum Publishers
Grad
New York (NY)
Godina
2000
Raspon stranica
269-270
ISBN
0-306-46217-6
Ključne riječi
Quantitative Structure-Activity Relationship (QSAR), COMBINE analysis, molecular modeling, gene regulation, molecular mechanics
Sažetak
To identify the major determinants of the DNA binding specificity of nuclear transcription factors, the Comparative Binding Energy (COMBINE) analysis has been performed. 3DQSAR models were derived for a set of 320 complexes of DNA and glucocorticoid receptor mutants, and the parameters important for determining binding specificity were identified.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
