Naslov
MRI Follow-Up of Brain Abnormalities in Congenital Cytomegalovirus Infection

Autori
Krakar, Goran ; Mejaški-Bošnjak, Vlatka ; Lončarević, Damir ; Gojmerac, Tomislav ; Borić, Igor ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Neuroimaging of Developmental Disorders - Book of abstracts, Dubrovnik, Hrvatska, 2009. / - , 2008

Skup
Neuroimaging of Developmental Disorders

Mjesto i datum
Dubrovnik, Hrvatska, 12.09.2009. - 16.09.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Congenital Cytomegalovirus Infection; CMV; neuroimaging

Sažetak
Objective: We report magnetic resonance imaging features in early infancy and follow-up of 5 children with congenital cytomegalovirus (CMV) infection. Materials and methods: All of our patients were symptomatic at neonatal age or referred during early infancy presenting with microcephaly, intrauterine growth retardation, deviant neuromotor development and neonatal hepatitis. CMV infection was diagnosed postnatally in all patients by polymerase chain reaction (PCR) of CMV DNA and serology on CMV-specific IgM and IgG antibodies. Magnetic resonance imaging (MRI) was performed during neonatal age and/or early infancy and follow-up at the 2-5yrs. Results: Our patients with congenital CMV infection show variety of brain abnormalities: ventriculomegaly, increased white matter signal intensity, leukoencephalopathy, delayed myelination or hypomyelination, broad spectrum of cortical dysgenesis (pachygyria and polymicrogyria), cystic cavities, corpus callosum hypoplasia, wide subarachnoidal spaces and cerebellar hypoplasia. At the age of 2-5 years MRI features changed in terms of white matter abnormalities, meaning that myelination improved, parenchymal cysts reduced with gliosis formation in some patients. Cerebellar hypoplasia and cortical dysgenesis remained unchanged. Conclusion: Affecting neurogenetic processes of cerebrum and cerebellum pre- and postnatally severity of brain abnormalities are related to the onset of congenital infection. Our patients represent broad spectrum of the effects of CMV on neurologic growth, development and maturation of central nervous system. Cortical malformations and cerebellar hypoplasia remain unchanged, whereas white matter abnormalities show evolution and improvement over the years.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA