Naslov
Neurotransmitori u simpatikusu
(Neurotransmitters in sympathetic system)

Autori
Zorc, Branka ; Knežević, Natalija

Izvornik
Farmaceutski glasnik (0014-8202) 56 (2000), 12; 429-436

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
neurotransmitor; simpatikus; adrenalin; noradrenalin; dopamin
(neurotransmitter; sympathetic system; adrenaline; noradrenaline; dopamine)

Sažetak
Noradrenaline (norepinephrine) and adrenaline (epinephrine) are direct-acting sympathomimetics. Their pharmacological effects are similar, but not identical. Noradrenaline has stronger interaction with a- and b1-receptors and adrenaline interacts similarly with all adrenergic receptors. Noradrenaline causes general vasocontriction with the exception of coronary arteries and, hence, increases systolic and diastolic blood pressure. It is used to provide haemodynamic support in various cardiovascular disorders. Adrenaline contracts blood vessels in the skin, mucosa and visceral tissues, but dilates blood vessels of the skeletal muscles and heart when given in low doses within the physiological range. It relaxes intestinal and bronchial muscle and has positive inotropic and chronotropic actions on the heart. Adrenaline has an important role in the management of acute allergic reactions and can be life saving in patients with anaphylactic shock. It is also used in advanced cardiac life support, for controling of minor bleeding, in ophtalmology as a mydriatic and for the management of certain type of glaucoma. It is frequently added to local anaesthetics to prolong the duration of effect and to lessen the toxicity. Dopamine is a neurotransmitter in the brain and a precursor of noradrenaline. It is both a direct- and indirect-acting sympathomimetic agent. It is employed for its inotropic effect. In the treatment of parkinsonism its precursor levodopa is used.

Izvorni jezik
Hrvatski

Znanstvena područja
Kemija

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