Naslov
Cerebellar glioblastomas : pathophysiology, clinical presentation and management

Autori
Grahovac, Gordan ; Tomac, Damir ; Lambaša, Smiljka ; Zorić, Arijana ; Habek, Mario

Izvornik
Acta neurochirurgica (0001-6268) 151 (2009), 6; 653-657

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
glioblastoma multiforme; cerebellum; primary glioblastoma; p53; p73

Sažetak
Glioblastoma multiforme usually affects the cerebral hemispheres with the peak age of onset in the sixth or seventh decade, while cerebellar glioblastoma multiforme is a rare tumour especially in younger patients. Most result from de-differentiation from low grade astrocytoma (secondary glioblastoma) or can develop de novo (primary glioblastoma). Primary glioblastomas develop in older patients while secondary glioblastomas develop in younger patients and contain TP53 mutations as the earliest detectable change. We report a 28 year old patient with primary multi-focal cerebellar glioblastoma multiforme and review the pathophisiology, clinical presentation, diagnosis and treatment of cerebellar glioblastomas.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA