Naslov
Prevalence of HBV genotypes in Central and Eastern Europe

Autori
Deterding, K. ; Constantinescu, I. ; Nedelcu, F.D. ; Gervain, J. ; Nemecek, V. ; Srtunecky, O. ; Vince, Adriana ; Grgurević, Ivica ; Bielawski, K.P. ; Zalewska, M. ; Bock, T. ; Ambrozaitis, A. ; Stanczak, J. ; Takács, M. ; Chulanov, V. ; Slusarczyk, J. ; Drazd'áková, M. ; Wiegand, J. ; Cornberg, M. ; Manns, M.P. ; Wedemeyer, H.

Izvornik
Journal of medical virology (0146-6615) 80 (2008), 10; 1707-1711

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HBV ; genotypes ; Central Europe

Sažetak
The importance of hepatitis B virus (HBV) genotypes for disease progression and response to interferon-alpha-based treatment is well established. While almost all patients in the Mediterranean area are infected with HBV genotype D, HBV genotype A is dominant in Northern Europe. However, the distribution of HBV genotypes is unknown for several Central and Eastern European countries. Data are described of 1313 HBsAg-positive patients recruited at 14 referral centers in eight countries. There were only very few cases of HBV genotype B, C, E, F, and H infection while HBV genotypes A and D were found in 42% and 48% of patients, respectively. Eight percent of patients had positive bands for more than one genotype using the hybridization assay. The frequency of genotype A was higher in Poland (77%) and the Czech Republic (67%) as compared to Hungary (47%), Lithuania (41%), Croatia (8%), and Germany (32%). In contrast, HBV genotype D was most frequent in Croatian, Romanian, and Russian patients with 80%, 67%, and 93% of cases, respectively. In conclusion, HBV genotype A versus D showed significantly different distribution patterns in Central and Eastern Europe which deserves consideration for national guidelines and treatment decisions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA