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Pregled bibliografske jedinice broj: 407836

Family-based analysis of tumor necrosis factor and lymphotoxin alpha tag polymorphisms and type 1 diabetes in the population of South Croatia.

Boraska, Vesna; Zeggini, Eleftheria; Groves, Christopher J; Rayner, Nigel W; Škrabić, Veselin; , Diakite, Mahamadou; Rockett, Kirk; Kwiatkowski, Dominic; McCarthey, Mark I; Zemunik, Tatijana
Family-based analysis of tumor necrosis factor and lymphotoxin alpha tag polymorphisms and type 1 diabetes in the population of South Croatia. // European Journal of Human Genetics
Barcelona, Španjolska, 2008. str. 356-356 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 407836 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Family-based analysis of tumor necrosis factor and lymphotoxin alpha tag polymorphisms and type 1 diabetes in the population of South Croatia.

Autori
Boraska, Vesna ; Zeggini, Eleftheria ; Groves, Christopher J ; Rayner, Nigel W ; Škrabić, Veselin ; , Diakite, Mahamadou ; Rockett, Kirk ; Kwiatkowski, Dominic ; McCarthey, Mark I ; Zemunik, Tatijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Human Genetics / - , 2008, 356-356

Skup
European Human Genetics Conference 2008

Mjesto i datum
Barcelona, Španjolska, 31.05.2008. - 03.06.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Type 1 diabetes; Tumor necrosis factor; Lymphotoxin alpha; TDT; Tag polymorphism

Sažetak
Type 1 diabetes is an autoimmune disease characterised by destruction of pancreatic beta cells. It is influenced by environmental and genetic factors. TNF and LTA are cytokines with a wide range of inflammatory and immunomodulatory activities possibly related with type 1 diabetes. The aim of the present study was to evaluate the association of 11 TNF/LTA tag polymorphisms in 160 type 1 diabetes trio families from South Croatia. Investigated tag polymorphisms were designed to capture the majority (62%) of common variation in TNF/LTA gene region, based on the HapMap database. We observed overtransmision of allels from parents to affected child at four variants: rs909253, allele C, p=1.2x10-4, rs1041981, allele A, p=1.1x10-4, rs1800629 (G-308A), allele A, p=1.2x10-4 and rs361525 (G-238A), allele G, p=8.2x10-3. We also identified overtransmission of the rs1800629(G-308A)-rs361525 (G-238A) G-A haplotype, p=2.384x10-5. The present study found an association of TNF/LTA gene region with type 1 diabetes. A careful assessment of TNF/LTA variants adjusted for linkage disequilibrium with HLA loci is needed to further clarify the role of these genes in type 1 diabetes susceptibility.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Projekti:
216-1080315-0293 - Genetska epidemiologija šećerne bolesti tip 1 u populaciji Hrvatske (Zemunik, Tatijana, MZOS ) ( CroRIS)

Ustanove:
KBC Split,
Medicinski fakultet, Split

Profili:

Avatar Url Tatijana Zemunik (autor)

Avatar Url Vesna Boraska Perica (autor)

Avatar Url Veselin Škrabić (autor)

Citiraj ovu publikaciju:

Boraska, Vesna; Zeggini, Eleftheria; Groves, Christopher J; Rayner, Nigel W; Škrabić, Veselin; , Diakite, Mahamadou; Rockett, Kirk; Kwiatkowski, Dominic; McCarthey, Mark I; Zemunik, Tatijana
Family-based analysis of tumor necrosis factor and lymphotoxin alpha tag polymorphisms and type 1 diabetes in the population of South Croatia. // European Journal of Human Genetics
Barcelona, Španjolska, 2008. str. 356-356 (poster, međunarodna recenzija, sažetak, znanstveni)
Boraska, V., Zeggini, E., Groves, C., Rayner, N., Škrabić, V., , Diakite, Mahamadou, Rockett, K., Kwiatkowski, D., McCarthey, M. & Zemunik, T. (2008) Family-based analysis of tumor necrosis factor and lymphotoxin alpha tag polymorphisms and type 1 diabetes in the population of South Croatia.. U: European Journal of Human Genetics.
@article{article, author = {Boraska, Vesna and Zeggini, Eleftheria and Groves, Christopher J and Rayner, Nigel W and \v{S}krabi\'{c}, Veselin and Rockett, Kirk and Kwiatkowski, Dominic and McCarthey, Mark I and Zemunik, Tatijana}, year = {2008}, pages = {356-356}, keywords = {Type 1 diabetes, Tumor necrosis factor, Lymphotoxin alpha, TDT, Tag polymorphism}, title = {Family-based analysis of tumor necrosis factor and lymphotoxin alpha tag polymorphisms and type 1 diabetes in the population of South Croatia.}, keyword = {Type 1 diabetes, Tumor necrosis factor, Lymphotoxin alpha, TDT, Tag polymorphism}, publisherplace = {Barcelona, \v{S}panjolska} }
@article{article, author = {Boraska, Vesna and Zeggini, Eleftheria and Groves, Christopher J and Rayner, Nigel W and \v{S}krabi\'{c}, Veselin and Rockett, Kirk and Kwiatkowski, Dominic and McCarthey, Mark I and Zemunik, Tatijana}, year = {2008}, pages = {356-356}, keywords = {Type 1 diabetes, Tumor necrosis factor, Lymphotoxin alpha, TDT, Tag polymorphism}, title = {Family-based analysis of tumor necrosis factor and lymphotoxin alpha tag polymorphisms and type 1 diabetes in the population of South Croatia.}, keyword = {Type 1 diabetes, Tumor necrosis factor, Lymphotoxin alpha, TDT, Tag polymorphism}, publisherplace = {Barcelona, \v{S}panjolska} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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