Naslov
Decreased risk for atopic disorder associated with highly hyperreactive tuberculin skin test reaction in children and adolescents

Autori
Maćešić, Marija ; Turkalj, Mirjana ; Jelčić, Žaneta ; Dodig, Slavica ; Kristić-Kirin, Branka ; Nogalo, Boro ; Plavec, Davor

Izvornik
Pediatric Pulmonology (8755-6863) 44 (2009), 7; 701-705

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Atopy; atopic disorder; hyperreactive tuberculin skin test; allergic sensitization; hygiene hypothesis

Sažetak
Abstract Background: It is speculated that the exposure to Mycobacterium tuberculosis, either by infection or by Bacillus Calmette-Guérin vaccination, may inhibit the onsetof atopy by the modification of immune profiles leading to a shift of TH1/TH2 balanceto the TH1 side. Objective: 186 patients hyperreactive at tuberculin skin test (TST) were examined in order to investigate the prevalence of atopic disorder, particularly referring to the association between the size of the TST induration and the prevalence of sensitization and manifest atopic disorder. Methods: The study consisted of a family history record, patients’ 23 medical history assessment and clinical examination, skin prick test (SPT), serum total and allergen-specific IgE (sIgE) measurement and eosinophil count. Results: Atopic disorder was present in 49 (26.3%) patients tested. No significant difference between the groups based on the TST induration size (15-24 mm vs. ≥ 25mm) was found for gender distribution, family atopy history, total IgE measurement, eosinophil count, positive SPT and the presence of sIgE. A significant difference was found for the age median (14.0 yrs vs. 13.0 yrs), childhood atopy record, and manifest atopic disorder. No association between the size of the TST induration and the incidence of allergic sensitization was demonstrated. However, a significant inverse association between the size of the TST induration and manifest atopic disorder was demonstrated. Conclusion: In patients highly hyperreactive at TST, the size of the induration is inversely associated with manifest atopic disorder. Clinical implications In children and adolescents a highly hyperreactive tuberculin skin test reaction is associated with a decreased risk for manifest atopic disorder. Capsule summary In patients highly hyperreactive at tuberculin skin test, the size of the induration is inversely associated with manifest atopic disorder

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA