Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 407023

The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects

Pivac, Nela; Nedić, Gordana; Mustapić, Maja; Babić, Ana; Stipčević, Tamara; Borovečki, Fran; Hajnšek, Sanja; Muck-Šeler, Dorotea
The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects // Neuroscience letters, 462 (2009), 1; 45-48 doi:10.1016/j.neulet.2009.06.080 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 407023 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects

Autori
Pivac, Nela ; Nedić, Gordana ; Mustapić, Maja ; Babić, Ana ; Stipčević, Tamara ; Borovečki, Fran ; Hajnšek, Sanja ; Muck-Šeler, Dorotea

Izvornik
Neuroscience letters (0304-3940) 462 (2009), 1; 45-48

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Healthy subjects ; Genetics ; Platelet serotonin concentration ; Serotonin transporter gene promoter polymorphism

Sažetak
A polymorphism in the serotonin transporter gene (5-HTTLPR) is frequently studied for association with antidepressant treatment response, different personality traits, and psychiatric disorders. Baseline platelet serotonin (5-HT) concentration has been proposed to indicate a good or a poor treatment response to antidepressant drugs and to be associated with particular symptoms in psychiatric disorders. The aim of the study was to elucidate the genotype-phenotype relationship between platelet 5-HT concentration and 5-HTTLPR in healthy subjects. The frequency of 5-HTTLPR genotypes and alleles, as well as platelet 5-HT concentration were evaluated in 434 male and 86 female unrelated healthy medication-free Caucasian subjects of Croatian origin. A two-way ANOVA revealed no significant difference in platelet 5-HT concentration subdivided according to the particular 5-HTTLPR genotype, no significant effect of sex (F=0.122 ; d.f.=1, 514 ; P=0.727), no significant effect of genotype (F=1.000 ; d.f.=2, 514 ; P=0.369), and no significant interaction between sex and genotype (F=2.031 ; d.f.=2, 514 ; P=0.132) on platelet 5-HT concentration. In addition, one-way ANOVAs did not detect significant effects of homozygous S/S genotype (F=1.401 ; d.f.=3, 516 ; P=0.242), or homozygous L/L genotype (F=1.690 ; d.f.=3, 516 ; P=0.168) on platelet 5-HT concentration. Our results showed a lack of significant association between platelet 5-HT concentration and 5-HTTLPR variants, suggesting that there is no functional relationship between 5-HTTLPR alleles and platelet 5-HT concentration in the large groups of healthy control male and female medication-free Caucasian subjects, free of neuro-psychiatric disorders.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( CroRIS)
108-1081874-1923 - Genomska analiza transkriptoma i interaktoma u bolesnika s kompleksnim bolestima (Borovečki, Fran, MZOS ) ( CroRIS)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Sanja Propadalo-Hajnšek (autor)

Avatar Url Ana Babić (autor)

Avatar Url Fran Borovečki (autor)

Avatar Url Tamara Stipčević (autor)

Avatar Url Gordana Nedić Erjavec (autor)

Avatar Url Dorotea Muck-Šeler (autor)

Avatar Url Nela Pivac (autor)

Avatar Url Maja Mustapić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Pivac, Nela; Nedić, Gordana; Mustapić, Maja; Babić, Ana; Stipčević, Tamara; Borovečki, Fran; Hajnšek, Sanja; Muck-Šeler, Dorotea
The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects // Neuroscience letters, 462 (2009), 1; 45-48 doi:10.1016/j.neulet.2009.06.080 (međunarodna recenzija, članak, znanstveni)
Pivac, N., Nedić, G., Mustapić, M., Babić, A., Stipčević, T., Borovečki, F., Hajnšek, S. & Muck-Šeler, D. (2009) The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects. Neuroscience letters, 462 (1), 45-48 doi:10.1016/j.neulet.2009.06.080.
@article{article, author = {Pivac, Nela and Nedi\'{c}, Gordana and Mustapi\'{c}, Maja and Babi\'{c}, Ana and Stip\v{c}evi\'{c}, Tamara and Borove\v{c}ki, Fran and Hajn\v{s}ek, Sanja and Muck-\v{S}eler, Dorotea}, year = {2009}, pages = {45-48}, DOI = {10.1016/j.neulet.2009.06.080}, keywords = {Healthy subjects, Genetics, Platelet serotonin concentration, Serotonin transporter gene promoter polymorphism}, journal = {Neuroscience letters}, doi = {10.1016/j.neulet.2009.06.080}, volume = {462}, number = {1}, issn = {0304-3940}, title = {The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects}, keyword = {Healthy subjects, Genetics, Platelet serotonin concentration, Serotonin transporter gene promoter polymorphism} }
@article{article, author = {Pivac, Nela and Nedi\'{c}, Gordana and Mustapi\'{c}, Maja and Babi\'{c}, Ana and Stip\v{c}evi\'{c}, Tamara and Borove\v{c}ki, Fran and Hajn\v{s}ek, Sanja and Muck-\v{S}eler, Dorotea}, year = {2009}, pages = {45-48}, DOI = {10.1016/j.neulet.2009.06.080}, keywords = {Healthy subjects, Genetics, Platelet serotonin concentration, Serotonin transporter gene promoter polymorphism}, journal = {Neuroscience letters}, doi = {10.1016/j.neulet.2009.06.080}, volume = {462}, number = {1}, issn = {0304-3940}, title = {The lack of genotype-phenotype relationship between platelet serotonin concentration and serotonin transporter gene promoter polymorphism in healthy subjects}, keyword = {Healthy subjects, Genetics, Platelet serotonin concentration, Serotonin transporter gene promoter polymorphism} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.