Naslov
Imidazolium and quinuclidinium compounds as antidotes in soman poisoning

Autori
Radić, Božica ; Lucić, Ana ; Peraica, Maja ; Domijan, Ana-Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Toxicology Letters / - Amsterdam : Elsevier, 2000, 98-98

Skup
EUROTOX 2000

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 17.09.2000. - 20.09.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
imidazolium; quinuclidinium; antidotes; soman

Sažetak
Series of imidazolium, quinuclidinium and pyridinium derivatives with different chains between rings and different substituents on the rings were tested in vitro on soman inhibited acetycholinesterase (AChE)of human erythrocytes and in vivo using soman poisoned mice. Pyridinium-quinuclidinium derivatives with oxime group at the position 2 of pyridinium ring. The tested compound are protective agents against soman intoxication in vivo, but their in vitro activity against soman inhibition of ADhE are negligible. The best effects in vivo were obtained by use of compounds containing quinuclidinium ring with carbamoyl group as substituents. The in vivo activity of the tested compounds should be attrributed to mechanisms still not well defined. All tested compounds were characterized by elemental analysis, IR and proton NMR-spectroscopy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA