Naslov
Ochratoxin A in blood of healthy population in Zagreb

Autori
Domijan, Ana-Marija ; Peraica, Maja ; Fuchs, Radovan ; Lucić, Ana ; Radić, Božica ; Balija, Melita ; Bosanac, Ivanka ; Grgičević, Damir

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 50 (1999), 3; 263-271

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Blood donors; endemic nephropathy; HPLC analysis; mycotoxins; ochratoxin A intake

Sažetak
Healthy blood donors from the city of Zagreb were checked for the presence of a nephrotoxic mycotoxin ochratoxin A (OTA) in the plasma. Samples of blood were collected in June, September, and December 1997, and March 1998, totalling 200 or 50 in each round. The concentrations of OTA were measured using high pressure liquid chromatography (HPLC) method (detection limit 0.2 ng OTA/ml of plasma). The frequency of OTA-positive samples (>0.2 ng/ml of plasma) showd significant seasonal variation (P<0.001). The frequency of OTA-positve samples was the highest in March (65 %) and it gradually decreased towards December (12 %). The high frequency of positive samples coincided with seasons favouring growth of moulds and production of toxins. The daily intake of OTA by healthy persons in Zagreb was estimated from the mean concentration of OTA in samples collected during the whole year (0.19 ng OTA/ml plasma). The estimated daily intake was 0.26 ng/kg b.w., that is, substantially below the tolerable daily intake proposed by World Health Organization (16.0 ng/kg b.w.).

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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