Naslov
Peroxidation and Age-Associated Diseases-Cause or Consequence?

Autori
Wildburger, Renate ; Mrakovčić, Lidija ; Štroser, Marina ; Andrišić, Luka ; Borović Šunjić, Suzana ; Žarković, Kamelija ; Žarković, Neven

Izvornik
Turkish journal of medical science (1300-0292) 29 (2009), 1; 189-193

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
aging ; oxidative stress ; lipid peroxidation ; 4-hydroxynonenal

Sažetak
Aging is progressive and deleterious process in many aspects common to all living organisms. In humans, development of various diseases, such as neurodegenerative diseases, cardiovascular diseases, some forms of cancer, metabolic disorders, diabetes, certain autoimmune and bone diseases, is proportional to aging. Therefore, it seems that excess in production of reactive oxygen species causing oxidative stress and lipid peroxidation plays important role in aging, homeostasis and initiation of age-associated diseases. Hence, oxidative stress and lipid peroxidation could be considered both as causative for particular age-associated diseases as well as cofactors of aging. However, constant but moderate oxidative stress might have beneficial impact upon increment of antioxidative capacities thus preventing initiation of age-associated diseases and extending aging.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA