Naslov
Correlation between synovial fluid and serum IL-1β levels after ACL surgery-preliminary report

Autori
Daraboš, Nikica ; Hundrić-Hašpl, Željka ; Hašpl, Miroslav ; Markotić, Alemka ; Daraboš, Anela ; Moser, Carsten

Izvornik
International orthopaedics (0341-2695) 33 (2009), 2; 413-418

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ACL surgery; synovial fluid and serum IL-1 ß

Sažetak
The possibility of controlling the harmful intra-articular influence of elevated interleukin (IL)-1β synovial fluid concentration after anterior cruciate ligament (ACL) surgery could be useful. We investigated the correlation between serum and synovial fluid IL-1β levels following ACL reconstruction. We measured IL-1β concentration periodically in three synovial fluid and four serum samples in each of 20 patients receiving either autologous conditioned serum (ACS) containing endogenous anti-inflammatory cytokines including IL-1Ra and several growth factors (group A) or placebo (group B). A decrease in IL-1β synovial fluid concentration appeared to be more pronounced in absolute terms in group A. In eight patients serum IL-1β was detected on the 6th postoperative day. In four of them whose synovial fluid levels were over 10 pg/ml on the 6th postoperative day, serum IL-1β was detected on the 10th postoperative day. The results were different in group B. Correlation between serum and synovial fluid IL-1β appearance persists in patients after ACL surgery and ACS application. This study is an example of ACS influence on the ACL healing process controlling the IL-1β levels on the basis of the serum IL-1β detection.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je kao poster prezentiran na skupu Combined SICOT/RCOST 2009 Annual Meeting, održanom od 29.10.-01.11.2009., Pattaya, Tajland

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