Naslov
Impaired lung function in children with allergic rhinitis without asthma

Autori
Mrkić Iva ; Plavec Davor ; Nogalo Boro ; Turkalj Mirjana.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Skup
7th Symposium on Expermental Rhinology and Immunology of the Nose

Mjesto i datum
Dubrovnik, Hrvatska, 13.11.2008. - 15.11.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Rhinitis; lung function; eNO

Sažetak
Inflammatory markers present in asthma can be elevated in patients with allergic rhinitis. Aim of our study was to evaluate lung function together with level of exhaled NO(eNO) in patients with allergic rhinitis without asthma.Subjects and methods:In a group of 51 children(31 male, 4-19 yrs) with diagnosed allergic rhinitis without asthma, we measured lung fuction, eNO, evaluated allergen sensitivity (skin prick tests, specific IgE) and therapy. Results: Twenty-two patients were allergic to pollen, 3 to mites, 10 to other perennial allergens, 12 to pollen and mites, and 3 were multisensitized. Spirometry showed restriction in 4% patients (FVC<80%predicted), while up to 13% had at least a distinct obstruction in the area of small airways (MEF25 or MEF50<80%), and up to 27% in the area of large airways (MEF75ofPEF<80%).Patients receiving intranasal corticosteroid (INCS)therapy plus antihistamines had the best PEF. In 25 patients we found elevated eNO. The lowest eNO values were found in patients receiving only INCS, and the highest in patients receiving triple rhinitis therapy(INCS+antihistamines+leukotriene antagonist).Significant correlation between eNO and lung function (FVC, P=0.004 ; FEV1, P=0.006) was found. Better lung function was found in patients with higher level of eNO.Conclusion: It seems that allergic rhinitis in children can be related to impaired lung function without clinical symptoms of lower airways.As these children may have increased risk for asthma they deserve further monitoring.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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