Naslov
Cholinesterases : substrate inhibition and substrate activation

Autori
Reiner, Elsa ; Simeon-Rudolf, Vera

Izvornik
Pflugers Archiv : European Journal of Physiology (0031-6768) 440 (2000), Suppl; R118-R120

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acetylcholinesterase; butyrylcholinesterase; catalytic constants

Sažetak
The relationship between activities and substrate concentrations (pS-curves) was analysed for reactions of acetylcholinesterase (EC 3.1.1.7) and butyrylcholinesterase (EC 3.1.1.8). Catalytic constants K-m, K-ss, V-m, n and b were calculated fi-om the Michaelis, Haldane, Hill and Webb equations in order to assess whether a given substrate also acts as an inhibitor or activator. It is suggested that the term substrate inhibition should only be attributed to substrates revealing bell-shaped pS-curves, while the terms apparent substrate inhibition or apparent substrate activation should relate to calculated values of the catalytic constants.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA