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Pregled bibliografske jedinice broj: 401709

Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries : the ARCAGE project

Canova, C.; Hashibe, M.; Simonato, L.; Nelis, M.; Metspalu, A.; Lagiou, P.; Trichopoulos, D.; Ahrens, W.; Pigeot, I.; Merletti, F. et al.
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries : the ARCAGE project // Cancer Research, 69 (2009), 7; 2956-2965 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 401709 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries : the ARCAGE project

Autori
Canova, C. ; Hashibe, M. ; Simonato, L. ; Nelis, M. ; Metspalu, A. ; Lagiou, P. ; Trichopoulos, D. ; Ahrens, W. ; Pigeot, I. ; Merletti, F. ; Richiardi, L. ; Talamini, R. ; Barzan, L. ; Macfarlane, G.J. ; Macfarlane, T.V. ; Holcátová, I. ; Bencko, V. ; Benhamou, S. ; Bouchardy, C. ; Kjaerheim, K. ; Lowry, R. ; Agudo, A. ; Castellsagué, X. ; Conway, D.I. ; McKinney, P.A. ; Znaor, Ariana ; McCartan, B.E. ; Healy, C.M. ; Marron, M. ; Brennan, P.

Izvornik
Cancer Research (0008-5472) 69 (2009), 7; 2956-2965

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
upper aerodigestive tract cancers; genetic polymorphisms

Sažetak
Cancers of the upper aerodigestive tract (UADT) include malignant tumors of the oral cavity, pharynx, larynx, and esophagus and account for 6.4% of all new cancers in Europe. In the context of a multicenter case-control study conducted in 14 centers within 10 European countries and comprising 1, 511 cases and 1, 457 controls (ARCAGE study), 115 single nucleotide polymorphisms (SNP) from 62 a priori-selected genes were studied in relation to UADT cancer. We found 11 SNPs that were statistically associated with UADT cancers overall (5.75 expected). Considering the possibility of false-positive results, we focused on SNPs in CYP2A6, MDM2, tumor necrosis factor (TNF), and gene amplified in squamous cell carcinoma 1 (GASC1), for which low P values for trend (P trend<0.01) were observed in the main effects analyses of UADT cancer overall or by subsite. The rare variant of CYP2A6 -47A>C (rs28399433), a phase I metabolism gene, was associated with reduced UADT cancer risk (P trend=0.01). Three SNPs in the MDM2 gene, involved in cell cycle control, were associated with UADT cancer. MDM2 IVS5+1285A>G (rs3730536) showed a strong codominant effect (P trend=0.007). The rare variants of two SNPs in the TNF gene were associated with a decreased risk ; for TNF IVS1+123G>A (rs1800610), the P trend was 0.007. Variants in two SNPs of GASC1 were found to be strongly associated with increased UADT cancer risk (for both, P trend=0.008). This study is the largest genetic epidemiologic study on UADT cancers in Europe. Our analysis points to potentially relevant genes in various pathways.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Projekti:
005-1080315-0294 - Odrednice multiplih primarnih sijela raka u populaciji (Znaor, Ariana, MZOS ) ( CroRIS)

Ustanove:
Hrvatski zavod za javno zdravstvo,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Ariana Znaor (autor)

Citiraj ovu publikaciju:

Canova, C.; Hashibe, M.; Simonato, L.; Nelis, M.; Metspalu, A.; Lagiou, P.; Trichopoulos, D.; Ahrens, W.; Pigeot, I.; Merletti, F. et al.
Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries : the ARCAGE project // Cancer Research, 69 (2009), 7; 2956-2965 (međunarodna recenzija, članak, znanstveni)
Canova, C., Hashibe, M., Simonato, L., Nelis, M., Metspalu, A., Lagiou, P., Trichopoulos, D., Ahrens, W., Pigeot, I. & Merletti, F. (2009) Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries : the ARCAGE project. Cancer Research, 69 (7), 2956-2965.
@article{article, author = {Canova, C. and Hashibe, M. and Simonato, L. and Nelis, M. and Metspalu, A. and Lagiou, P. and Trichopoulos, D. and Ahrens, W. and Pigeot, I. and Merletti, F. and Richiardi, L. and Talamini, R. and Barzan, L. and Macfarlane, G.J. and Macfarlane, T.V. and Holc\'{a}tov\'{a}, I. and Bencko, V. and Benhamou, S. and Bouchardy, C. and Kjaerheim, K. and Lowry, R. and Agudo, A. and Castellsagu\'{e}, X. and Conway, D.I. and McKinney, P.A. and Znaor, Ariana and McCartan, B.E. and Healy, C.M. and Marron, M. and Brennan, P.}, year = {2009}, pages = {2956-2965}, keywords = {upper aerodigestive tract cancers, genetic polymorphisms}, journal = {Cancer Research}, volume = {69}, number = {7}, issn = {0008-5472}, title = {Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries : the ARCAGE project}, keyword = {upper aerodigestive tract cancers, genetic polymorphisms} }
@article{article, author = {Canova, C. and Hashibe, M. and Simonato, L. and Nelis, M. and Metspalu, A. and Lagiou, P. and Trichopoulos, D. and Ahrens, W. and Pigeot, I. and Merletti, F. and Richiardi, L. and Talamini, R. and Barzan, L. and Macfarlane, G.J. and Macfarlane, T.V. and Holc\'{a}tov\'{a}, I. and Bencko, V. and Benhamou, S. and Bouchardy, C. and Kjaerheim, K. and Lowry, R. and Agudo, A. and Castellsagu\'{e}, X. and Conway, D.I. and McKinney, P.A. and Znaor, Ariana and McCartan, B.E. and Healy, C.M. and Marron, M. and Brennan, P.}, year = {2009}, pages = {2956-2965}, keywords = {upper aerodigestive tract cancers, genetic polymorphisms}, journal = {Cancer Research}, volume = {69}, number = {7}, issn = {0008-5472}, title = {Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries : the ARCAGE project}, keyword = {upper aerodigestive tract cancers, genetic polymorphisms} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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