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Pregled bibliografske jedinice broj: 400900

Multiple ADH genes are associated with upper aerodigestive cancers

Hashibe, M.; McKay, J.D.; Curado, M.P.; Oliveira, J.C.; Koifman, S.; Koifman, R.; Zaridze, D.; Shangina, O.; Wünsch-Filho, V.; Eluf-Neto, J. et al.
Multiple ADH genes are associated with upper aerodigestive cancers // Nature genetics, 40 (2008), 6; 707-709 (međunarodna recenzija, pismo, znanstveni)

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Naslov
Multiple ADH genes are associated with upper aerodigestive cancers

Autori
Hashibe, M. ; McKay, J.D. ; Curado, M.P. ; Oliveira, J.C. ; Koifman, S. ; Koifman, R. ; Zaridze, D. ; Shangina, O. ; Wünsch-Filho, V. ; Eluf-Neto, J. ; Levi, J.E. ; Matos, E. ; Lagiou, P. ; Lagiou, E. ; Benhamou, S. ; Bouchardy, C. ; Szeszenia-Dabrowska, N. ; Menezes, A. ; Dall’ Agnol, M.M. ; Merletti, F. ; Richiardi, L. ; Fernandez, L. ; Lence, J. ; Talamini, R. ; Barzan, L. ; Mates, D. ; Mates, I.N. ; Kjaerheim, K. ; Macfarlane, G.J. ; Macfarlane, T.V. ; Simonato, L. ; Canova, C. ; Holcatova, I. ; Agudo, A. ; Castellsague, X. ; Lowry, R. ; Janout, V. ; Kollarova, H. ; Conway, D.I. ; McKinney, P.A. ; Znaor, Ariana ; Fabianova, E. ; Bencko, V. ; Lissowska, J. ; Chabrier, A. ; Hung, R.J. ; Gaborieau, V. ; Boffetta, P. ; Brennan, P.

Izvornik
Nature genetics (1061-4036) 40 (2008), 6; 707-709

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
ADH genes; upper aerodigestive cancers

Sažetak
Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3, 800 aerodigestive cancer cases and 5, 200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA

Ustanove:
Hrvatski zavod za javno zdravstvo

Profili:

Avatar Url Neven Mates (autor)

Avatar Url Ariana Znaor (autor)

Citiraj ovu publikaciju:

Hashibe, M.; McKay, J.D.; Curado, M.P.; Oliveira, J.C.; Koifman, S.; Koifman, R.; Zaridze, D.; Shangina, O.; Wünsch-Filho, V.; Eluf-Neto, J. et al.
Multiple ADH genes are associated with upper aerodigestive cancers // Nature genetics, 40 (2008), 6; 707-709 (međunarodna recenzija, pismo, znanstveni)
Hashibe, M., McKay, J., Curado, M., Oliveira, J., Koifman, S., Koifman, R., Zaridze, D., Shangina, O., Wünsch-Filho, V. & Eluf-Neto, J. (2008) Multiple ADH genes are associated with upper aerodigestive cancers. Nature genetics, 40 (6), 707-709.
@article{article, author = {Hashibe, M. and McKay, J.D. and Curado, M.P. and Oliveira, J.C. and Koifman, S. and Koifman, R. and Zaridze, D. and Shangina, O. and W\"{u}nsch-Filho, V. and Eluf-Neto, J. and Levi, J.E. and Matos, E. and Lagiou, P. and Lagiou, E. and Benhamou, S. and Bouchardy, C. and Szeszenia-Dabrowska, N. and Menezes, A. and Agnol, M.M. and Merletti, F. and Richiardi, L. and Fernandez, L. and Lence, J. and Talamini, R. and Barzan, L. and Mates, D. and Mates, I.N. and Kjaerheim, K. and Macfarlane, G.J. and Macfarlane, T.V. and Simonato, L. and Canova, C. and Holcatova, I. and Agudo, A. and Castellsague, X. and Lowry, R. and Janout, V. and Kollarova, H. and Conway, D.I. and McKinney, P.A. and Znaor, Ariana and Fabianova, E. and Bencko, V. and Lissowska, J. and Chabrier, A. and Hung, R.J. and Gaborieau, V. and Boffetta, P. and Brennan, P.}, year = {2008}, pages = {707-709}, keywords = {ADH genes, upper aerodigestive cancers}, journal = {Nature genetics}, volume = {40}, number = {6}, issn = {1061-4036}, title = {Multiple ADH genes are associated with upper aerodigestive cancers}, keyword = {ADH genes, upper aerodigestive cancers} }
@article{article, author = {Hashibe, M. and McKay, J.D. and Curado, M.P. and Oliveira, J.C. and Koifman, S. and Koifman, R. and Zaridze, D. and Shangina, O. and W\"{u}nsch-Filho, V. and Eluf-Neto, J. and Levi, J.E. and Matos, E. and Lagiou, P. and Lagiou, E. and Benhamou, S. and Bouchardy, C. and Szeszenia-Dabrowska, N. and Menezes, A. and Agnol, M.M. and Merletti, F. and Richiardi, L. and Fernandez, L. and Lence, J. and Talamini, R. and Barzan, L. and Mates, D. and Mates, I.N. and Kjaerheim, K. and Macfarlane, G.J. and Macfarlane, T.V. and Simonato, L. and Canova, C. and Holcatova, I. and Agudo, A. and Castellsague, X. and Lowry, R. and Janout, V. and Kollarova, H. and Conway, D.I. and McKinney, P.A. and Znaor, Ariana and Fabianova, E. and Bencko, V. and Lissowska, J. and Chabrier, A. and Hung, R.J. and Gaborieau, V. and Boffetta, P. and Brennan, P.}, year = {2008}, pages = {707-709}, keywords = {ADH genes, upper aerodigestive cancers}, journal = {Nature genetics}, volume = {40}, number = {6}, issn = {1061-4036}, title = {Multiple ADH genes are associated with upper aerodigestive cancers}, keyword = {ADH genes, upper aerodigestive cancers} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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