Naslov
Antimicrobial Drug Use and Resistance in Europe

Autori
Van de Sande-Bruinsma, Nienke ; Grundmann, Hajo ; Verloo, Didier ; Tiemersma, Edine ; Monen, Jos ; Goossens, Herman ; Ferech, Matus and the European Antimicrobial Resistance Surveillance System and European Surveillance of Antimicrobial Consumption Project Groups

Izvornik
Emerging Infectious Diseases (1080-6040) 14 (2008), 11; 1722-1730

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antimicrobial agents; ambulatory care; resistance trends; 2 major pathogens;

Sažetak
Our study confronts the use of antimicrobial agents in ambulatory care with the resistance trends of 2 major pathogens, Streptococcus pneumoniae and Escherichia coli, in 21 European countries in 2000– 2005 and explores whether the notion that antimicrobial drug use determines resistance can be supported by surveillance data at national aggregation levels. The data obtained from the European Surveillance of Antimicrobial Consumption and the European Antimicrobial Resistance Surveillance System suggest that variation of consumption coincides with the occurrence of resistance at the country level. Linear regression analysis showed that the association between antimicrobial drug use and resistance was specifi c and robust for 2 of 3 compound pathogen combinations, stable over time, but not sensitive enough to explain all of the observed variations. Ecologic studies based on routine surveillance data indicate a relation between use and resistance and support interventions designed to reduce antimicrobial drug consumption at a national level in Europe.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA