Naslov
Trefoil factor family proteins in gastrointestinal defense

Autori
Lubka, Maria ; Blin, Nikolaus ; Baus-Lončar Mirela

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Biochemistry and Immunology Intersections

Urednik/ci
Markotic, Anita ; Glavaš-Obrovac, Ljubica ; Varljen , Jadranka ; Žanic-Grubišic, Tihana

Izdavač
Research Signpost

Grad
Lahti

Godina
2008

Raspon stranica
1-28

ISBN
978-81-308-0265-7

Ključne riječi
TFFs, gastrintestinal tract, protective effects

Sažetak
Epithelial tissues of the gastrointestinal (GI) tract constitute one of the most extended surfaces exposed to outer world and as such a most intensive battlefield of the immune system. Various factors and mechanisms are involved in mucosal protection. In recent years a group of small peptides, the so called TFF (trefoil factor family) proteins TFF1, TFF2 and TFF3, emerged as important players in GI mucosal protection. The location of TFFs’ highest expression is GI tissue where they are secreted into the lumen of the GI tract. Trefoil proteins in GI tissue exhibit various protective effects increasing the restitution of injured mucosa. The mode of their action is complex and includes: a) formation and stabilization of mucous barrier, b) enhancement of fast tissue repair (known as restitution), c) modulation of mucosal differentiation and d)modulation of immune response. Moreover, presence of TFFs in some other tissues (brain, lung, pancreas, mammary gland, inner ear, lymphoid tissue and serum) likely points to their more general role in the organism. The modulation of immune response by TFFs in the GI tract could be the most effective way of action, regulating a variety of processes and maintaining immunological homeostasis.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA