Naslov
Seryl-tRNA Synthetases : Enzymes with Multiple Personalities

Autori
Bilokapić, Silvija ; Ban, Nenad ; Weygand-Đurašević, Ivana

Izvornik
Croatica Chemica Acta (0011-1643) 82 (2009), 1; 51-59

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
seryl-tRNA synthetase; transfer RNA; synthetase crystal structure; synthetase:tRNA model

Sažetak
Seryl-tRNA synthetases (SerRS) are essential enzymes responsible for aminoacylation of cognate transfer-RNAs (tRNAsSer) with serine, which is then incorporated into the proteins being synthesized on the ribosome. Although tRNA synthetases are usually a very conserved class of enzymes, phylogenic analyses revealed the existence of two distinct types of serine-charging enzymes ; a standard or bacterial-type SerRS is found in the majority of organisms (prokaryotes, eukaryotes and archaea), while a highly diverged methanogenic-type SerRS is confined to the methanogenic archaea. We give a short overview on our recent biochemical and structural contributions to the understanding of different molecular mecha-nisms of tRNA serylation.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA