Naslov
Is nasal hyperreactive response to non-isotonic aerosol related to the level of inflammation

Autori
Zurak, Krešo ; Vagić, Davor ; Baudoin, Tomislav ; Solter, Darko ; Kalogjera, Livije

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract book of the 7th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN) / Scadding, Glenis ; Kalogjera, Livije - Zagreb, 2008

Skup
7th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN)

Mjesto i datum
Dubrovnik, Hrvatska, 13.11.2008. - 15.11.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Rhinitis - allergic; non-allergic; nasal hyperreactivity

Sažetak
A significant increase in nasal resistance is observed in patients with allergic and non-allergic rhinitis after nasal inhalation of distilled water mist. The purpose of the study was to compare hyperreactive response to nasal distilled water provocation in the patients with allergic and non-allergic hyperreactive rhinitis with the level of inflammatory cell activation markers prior to provocation. The study was performed on a group of 78 patients with nasal hyperreactivity according to patient history, 48 patients with allergic rhinitis and 30 patients with non-infectious non-allergic rhinitis (NINAR). The concentrations of eosinophil cationic protein (ECP), myeloperoxidase (MPO) and tryptase (TRY) were measured in the nasal lavage prior to provocation. Basal nasal airway resistance (NAR) was measured by active anterior rhinomanometry, and nasal lavage with 5 ccm of saline was taken. The provocation was made by inhalation of 10 ccm of distilled water during 10 minutes. The patients were divided in three subgroups according to NAR increase (0, 50%, 100%). Tryptase concentration in the nasal lavage and a relative eosinophil number were significantly higher in allergic than non-allergic patients. No correlation was found between the relative number of eosinophils and degree of nasal hyperreactivity. Likewise no correlation was found between any of the cellular markers and level of nasal hyperreactivity, and no difference in marker levels between the groups. The correlation between ECP and MPO in nasal lavage was significant. Since there is no correlation between inflammatory cell activation and the degree of nasal hyperreactivity, it may be concluded that neural reflexes leading to nasal congestion after non-isotonic aerosol inhalation are not dependent on the level of inflammation measured bythe activation of granulocytes and mastocytes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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