Naslov
Relation between cellular infiltration and markers in patients with chronic rhinosinusitis

Autori
Vagić, Davor ; Kalogjera, Livije ; Baudoin, Tomislav ; Zurak, Krešo ; Geber, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstract book of the 7th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN) / Scadding, Glenis ; Kalogjera, Livije - Zagreb, 2008

Skup
7th Symposium on Experimental Rhinology and Immunology of the Nose (SERIN)

Mjesto i datum
Dubrovnik, Hrvatska, 13.11.2008. - 15.11.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
asthmatic patients; chronic rhinosinusitis; inflammation; eosinophil activation

Sažetak
The aim of the study was to show the difference in the pattern of inflammation between asthmatic and non-asthmatic patients with CRS. Eosinophil activation, local IgE levels in the sinus fluid and tissue, and the severity of inflammation were measured. The maxillary sinus lavages, mucosal biopsies and bacteriological swabs were taken in 23 asthmatic and 36 non-asthmatic adult patients with CRS. The concentrations of IgE, eosinophil cationic protein (ECP), myeloperoxidase (MPO), and tryptase were analyzed and IgE+ cells, eosinophils, lymphocytes and plasma cells counted. The granulocyte activation markers and IgE in sinus lavages, and the inflammatory and IgE+ cells counts were significantly higher in the asthmatics with the greatest difference in ECP and IgE concentrations. The tryptase concentrations did not differ, but only in the asthmatics they correlated significantly with the IgE concentrations and IgE+ cells count. Subjective scores were decreased after therapy in both groups of patients and without correlation to objective parameters of inflammation. Asthmatic patients present a distinct subgroup among the patients with chronic rhinosinusitis (CRS). The levels of the cellular markers and IgE in the sinus fluid differ from those of non-asthmatic patients with CRS. The activation of granulocytes (especially eosinophils), local IgE concentrations and the inflammatory cells infiltration are significantly higher in the asthmatics.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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