Naslov
Abnormalities of midsagittal corpus callosum area in children with perinatal injury of the periventricular crossroads of pathways

Autori
Čuljat, Marko ; Benjak, Vesna ; Ozretić, David ; Kostović, Ivica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book - PENS-Blackwell Summer School 2007 / - , 2007

Skup
PENS-Blackwell Summer School 2007: Advanced Course in Neuroplasticity

Mjesto i datum
Rim, Italija, 05.09.2007. - 11.09.2007

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
corpus callosum; crossroad of pathways; magnetic resonance; ultrasound

Sažetak
BACKGROUND: Hypoxic-ischemic lesions frequently occur in preterm infants. These lesions damage the periventricular crossroads of commissural, projection and associative pathways, and are associated with frequent co-occurrence of motor, sensory and cognitive deficits. METHODS: We explored to what extent abnormalities of echogenicity of the periventricular crossroads correlate with changes in size of the corpus callosum. Our study included seven infants, gestation ages from 26-41 weeks, with perinatal brain injury. Periventricular areas of frontal, main and occipital crossroads were visualized by cranial ultrasound scans, performed during the first ten days after birth. The degree of echogenicity of white matter on US scans was scored on a linear analog scale from 0 to 3 compared to the echogenicity of the plexus choroideus, the grade 3 being given to the areas with the same echogenicity as the plexus (0 – normal echogenicity, 1- mild increase in echogenicity, 2 – moderate increase in echogenicity, 3 – severe increase in echogenicity). By adding the ultrasound intensity grades of all three crossroad areas of both sides, we got the range from 0 (normal echogenicity in all three crossroad areas on both sides) to 18 (severely increased echogenicity in all the crossroads on both sides). Corpus callosum midsagittal area measurements were performed on magnetic resonance images, acquired at term equivalent. RESULTS: The relationship between the corpus callosum midsagittal area and the sum of the crossroad echogenicities was statistically analyzed using the Pearson’ s correlation test. The calculated quotient (r) was – 0.8574, showing that the higher combined echogenicity of all the crossroad areas is in correlation with the smaller midsagittal area of the corpus callosum (p<0.05). CONCLUSIONS: In our study, areas of frontal, main and occipital periventricular crossroads, which contain a periventricular front of growing callosal fibers, show varying degrees of hyperechodensities. These abnormal changes were frequently associated with a significant reduction of callosal midsagittal area. Our data supports the hypothesis that corpus callosum fibers can be damaged during growth through the periventricular crossroads of pathways in the vulnerable preterm period, in which there is intensive growth and remodeling with increased requirement of axonal guidance with extracellular matrix molecules.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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